Implication of LncRNAs MEG3 and LINC00305 in Pathophysiological Mechanisms associated with Rheumatoid Arthritis
Wahba, A., Ibrahim, M., Mesbah, N., Saleh, S., Abo-El-Matty, D., Mehanna, E. (2021). Implication of LncRNAs MEG3 and LINC00305 in Pathophysiological Mechanisms associated with Rheumatoid Arthritis. EKB Journal Management System, 5(Chemistry), 8-17. doi: 10.21608/rpbs.2020.32723.1068
Alaa Samir Wahba; Maha Emad Ibrahim; Noha Mesbah; Samy Saleh; Dina Abo-El-Matty; Eman T. Mehanna. "Implication of LncRNAs MEG3 and LINC00305 in Pathophysiological Mechanisms associated with Rheumatoid Arthritis". EKB Journal Management System, 5, Chemistry, 2021, 8-17. doi: 10.21608/rpbs.2020.32723.1068
Wahba, A., Ibrahim, M., Mesbah, N., Saleh, S., Abo-El-Matty, D., Mehanna, E. (2021). 'Implication of LncRNAs MEG3 and LINC00305 in Pathophysiological Mechanisms associated with Rheumatoid Arthritis', EKB Journal Management System, 5(Chemistry), pp. 8-17. doi: 10.21608/rpbs.2020.32723.1068
Wahba, A., Ibrahim, M., Mesbah, N., Saleh, S., Abo-El-Matty, D., Mehanna, E. Implication of LncRNAs MEG3 and LINC00305 in Pathophysiological Mechanisms associated with Rheumatoid Arthritis. EKB Journal Management System, 2021; 5(Chemistry): 8-17. doi: 10.21608/rpbs.2020.32723.1068

Implication of LncRNAs MEG3 and LINC00305 in Pathophysiological Mechanisms associated with Rheumatoid Arthritis

Records of Pharmaceutical and Biomedical Sciences
Article 5, Volume 5, Chemistry - Serial Number 1, January 2021, Page 8-17  XML PDF (784.79 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2020.32723.1068
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Authors
Alaa Samir Wahba email orcid 1; Maha Emad Ibrahimorcid 2; Noha Mesbahorcid 1; Samy Saleh1; Dina Abo-El-Mattyorcid 1; Eman T. Mehannaorcid 1
1Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
2Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Rheumatoid arthritis (RA) is a joint destructive disorder with great morbidity. Early diagnosis and early and effective therapy may prevent joint damage and lead to better long-term results. Therefore, reliable biomarkers and outcome measures are needed. Complex interplay between multiple risk factors contributes to RA. These risk factors include environmental factors, genetic factors and epigenetic modifications. Long non-coding RNAs (lncRNAs) are involved in these epigenetic mechanisms. Accumulating evidence has shown that lncRNAs participate in the processes of inflammation, aberrant proliferation, apoptosis and angiogenesis. They also play roles in autoimmune diseases, such as SLE, Sjogren syndrome, RA and multiple sclerosis. Maternally expressed gene 3 (MEG3) is a maternally expressed lncRNA of the imprinted DLK1–MEG3 locus located on human 14q32 chromosome. It functions as a tumor suppressor. Decreased MEG3 expression has been observed in various human cancers, both type 1 and type 2 diabetes, osteoarthritis and in RA. Decreased serum levels of lncRNA MEG3 in RA could be attributed to MEG3 promoter hypermethylation induced by hypoxia. This downregulation was associated with increased inflammation, cell proliferation and cell invasion and decreased apoptosis. Long intergenic non-Protein coding RNA 00305 (LINC00305) was identified as a pro-inflammatory atherosclerosis-associated lncRNA. RA was associated with increased LINC00305 which served as a regulator of inflammatory, hypoxic, invasive, apoptotic and proliferative mechanisms associated with RA.
Keywords
Rheumatoid arthritis; MEG3; LINC00305
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