Nano-formulations for Different Treatment Modalities to Overcome Multi Drug Resistance in Hepatocellular Carcinoma | ||||
| Records of Pharmaceutical and Biomedical Sciences | ||||
| Article 11, Volume 5, Chemistry - Serial Number 1, January 2021, Page 65-77 PDF (642.69 K) | ||||
| Document Type: Mini-reviews | ||||
| DOI: 10.21608/rpbs.2020.26710.1057 | ||||
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| Authors | ||||
Hend Abo Mansour   1; Maha El-Batsh2; Nadia S Badawy3; Eman T. Mehanna 4; Noha M Mesbah 5; Dina M Abo-El-Matty 6
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| 1Department of Biochemistry, Faculty of Pharmacy, Menoufia University, Egypt | ||||
| 2Department of Clinical Pharmacology, Faculty of Medicine, Menoufia University, Egypt. | ||||
| 3Department of Histology and Cell Biology, Faculty of Medicine, Menoufia University, Egypt. | ||||
| 4Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt | ||||
| 5Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt | ||||
| 6Faculty of Pharmacy - Suez Canal University | ||||
| Abstract | ||||
| Hepatocellular carcinoma (HCC) is one of the most common malignancies and it is the fourth cause of cancer-related mortality. The treatment of HCC with traditional chemotherapeutic agents such as doxorubicin has been limited due to poor efficacy, acquired resistance of the tumors and systemic toxicity. Verapamil as a P-gp inhibitor has demonstrated anti-cancer activities both in vitro and in vivo. Natural products and plant-derived compounds, such as ginger extract, have been investigated as safe and effective anti-cancer agents. Combination therapy offers preferable prognosis with less side effects. For example, the combination of chemotherapeutics with verapamil or ginger extract has been shown to exert beneficial therapeutic effects, overcome multidrug resistance and reduce side effects through modulation of different signaling pathways in tumor cells. Nano-sized formulations are designed to increase accumulation of drugs at the tumor environment and to improve solubility/bioavailability, promote retention, specificity, efficacy and safety. This review summarizes how to overcome cardiotoxicity and multidrug resistance evolved by doxorubicin in HCC treatment. | ||||
| Keywords | ||||
| Doxorubicin; Ginger extract; Hepatocellular carcinoma; Nano-sized formulations; Verapamil | ||||
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