The cluster of differentiation-36 (CD-36) as a promising marker for many diseases
Fakhry, M., Ramadan, A., Abo-El-Matty, D., Mesbah, N., Sawaf, A., Ezzat, O., Sawaf, H. (2021). The cluster of differentiation-36 (CD-36) as a promising marker for many diseases. EKB Journal Management System, 5(Chemistry), 78-82. doi: 10.21608/rpbs.2020.23117.1051
Morkoss Fakhry; Asma Ramadan; Dina Abo-El-Matty; Noha Mesbah; Ahmed Sawaf; Omnia Ezzat; Hussein Sawaf. "The cluster of differentiation-36 (CD-36) as a promising marker for many diseases". EKB Journal Management System, 5, Chemistry, 2021, 78-82. doi: 10.21608/rpbs.2020.23117.1051
Fakhry, M., Ramadan, A., Abo-El-Matty, D., Mesbah, N., Sawaf, A., Ezzat, O., Sawaf, H. (2021). 'The cluster of differentiation-36 (CD-36) as a promising marker for many diseases', EKB Journal Management System, 5(Chemistry), pp. 78-82. doi: 10.21608/rpbs.2020.23117.1051
Fakhry, M., Ramadan, A., Abo-El-Matty, D., Mesbah, N., Sawaf, A., Ezzat, O., Sawaf, H. The cluster of differentiation-36 (CD-36) as a promising marker for many diseases. EKB Journal Management System, 2021; 5(Chemistry): 78-82. doi: 10.21608/rpbs.2020.23117.1051

The cluster of differentiation-36 (CD-36) as a promising marker for many diseases

Records of Pharmaceutical and Biomedical Sciences
Article 12, Volume 5, Chemistry - Serial Number 1, January 2021, Page 78-82  XML PDF (234.12 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2020.23117.1051
View on SCiNiTO View on SCiNiTO
Authors
Morkoss Fakhry email 1; Asma Ramadan2; Dina Abo-El-Mattyorcid 3; Noha Mesbahorcid 2; Ahmed Sawaf4; Omnia Ezzat5; Hussein Sawaf5
1Biochemistry department,Faculty of pharmacy,Egyptian Russian University
2Biochemistry Department, Faculty of Pharmacy, Suez Canal University. Ismailia- Egypt
3Faculty of Pharmacy - Suez Canal University
4Gynacology and obstetrics Department, Faculty of Medicine, Cairo University. Cairo- Egypt
5. Department of Biochemistry , Faculty of Pharmacy, Egyptian Russian University. Cairo - Egypt
Abstract
CD36 is a transmembrane protein involved in fatty acid translocation, scavenging for oxidized fatty acids acting as a receptor for adhesion molecules. It is expressed on macrophages, as well as other types of cells, such as endothelial and adipose cells. CD36 participates in muscle lipid uptake, adipose energy storage, and gut fat absorption. Recently, several preclinical and clinical studies demonstrated that the upregulation of CD36 is a prerequisite for tumor metastasis. Cancer metastasis-related research emerged much later and has been less investigated, though it is equally or even more important. CD36 protein expression can be modified by epigenetic changes and post-transcriptional interference from non-coding RNAs. Some data indicate modulation of CD36 expression in specific cell types by epigenetic changes via DNA methylation patterns or histone tails, or through miRNA interference, but this is largely unexplored. The few papers addressing this topic refer mostly to lipid metabolism-related pathologies, whereas in cancer research, data are even more scarce. The aim of this review was to summarize major epigenetic and post-transcriptional mechanisms that impact CD36 expression in relation to various pathologies while highlighting the areas in need of further exploration.
Keywords
CD-36; Marker; Cluster
Statistics
Article View: 294
PDF Download: 269