Review Article on Rhodanine Ring
abdel Aziz, Y., Salem, M., Elewa, M., El shihawy, H., Said, M. (2021). Review Article on Rhodanine Ring. EKB Journal Management System, 5(Chemistry), 83-89. doi: 10.21608/rpbs.2021.30184.1063
yasmine mohamed abdel Aziz; Manar Salem; Marwa Elewa; Hosam El shihawy; Mohamed Said. "Review Article on Rhodanine Ring". EKB Journal Management System, 5, Chemistry, 2021, 83-89. doi: 10.21608/rpbs.2021.30184.1063
abdel Aziz, Y., Salem, M., Elewa, M., El shihawy, H., Said, M. (2021). 'Review Article on Rhodanine Ring', EKB Journal Management System, 5(Chemistry), pp. 83-89. doi: 10.21608/rpbs.2021.30184.1063
abdel Aziz, Y., Salem, M., Elewa, M., El shihawy, H., Said, M. Review Article on Rhodanine Ring. EKB Journal Management System, 2021; 5(Chemistry): 83-89. doi: 10.21608/rpbs.2021.30184.1063

Review Article on Rhodanine Ring

Records of Pharmaceutical and Biomedical Sciences
Article 13, Volume 5, Chemistry - Serial Number 1, January 2021, Page 83-89  XML PDF (856.67 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2021.30184.1063
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Authors
yasmine mohamed abdel Aziz email orcid 1; Manar Salem2; Marwa Elewaorcid 3; Hosam El shihawy2; Mohamed Said2
1pharmaceutical organic chemistry faculty of pharmacy Suez canal university
2Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
3Organic chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
Abstract
A review article described the chemistry of 4-thiazolidinones particularly rhodanine ring and different approaches for its reactions which included the modification of the ring. Besides, the reactivity of rhodanine ring which helped in the synthesis of different arylidenes at position 5 and carboxylic acids at position 3 The most reactive positions in 4-thiazolidinone are 3 and 5, which determine the major directions of heterocycle modification. Approaches to the synthesis of 3,5-disubstituted 4-thiazolidinones in general include two pathways. The first one was throughout the synthesis of 3,5-disubstituted 4-thiazolidinones by different reactions in position 3 of the thiazolidinone cycle. The second was the synthesis of 3,5-disubstituted 4-thiazolidinones by diverse reactions in position 5 of the thiazolidinone cycle Modification of 4-thiazolidinone cycle on positions 2, 3, 4 or 5 was successful to achieve synthetic products with a wide spectrum of pharmacological activity Currently 4-thiazolidinones were considered as a new class of antidiabetic (insulinsensitizing) drugs and potent aldose reductase inhibitors, which possess the potential for the treatment of diabetes complications (cataract, nephropathy, neuropathy).
Keywords
Rhodanine; 4-Thiazolidinones; Methylene Carbon; Synthesis; SN2 Type
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