Association of Human Beta – Defensin 1 Gene Polymorphisms with Alopecia Areata Patients
Ibrahim, A., Alhusseiny, N., Mustafa, A., Yousef, A. (2020). Association of Human Beta – Defensin 1 Gene Polymorphisms with Alopecia Areata Patients. EKB Journal Management System, 5(Issue 1 part (1)), 53-56. doi: 10.21608/bjas.2020.135746
A.A. Ibrahim; N.F. Alhusseiny; A.I. Mustafa; A.S. Yousef. "Association of Human Beta – Defensin 1 Gene Polymorphisms with Alopecia Areata Patients". EKB Journal Management System, 5, Issue 1 part (1), 2020, 53-56. doi: 10.21608/bjas.2020.135746
Ibrahim, A., Alhusseiny, N., Mustafa, A., Yousef, A. (2020). 'Association of Human Beta – Defensin 1 Gene Polymorphisms with Alopecia Areata Patients', EKB Journal Management System, 5(Issue 1 part (1)), pp. 53-56. doi: 10.21608/bjas.2020.135746
Ibrahim, A., Alhusseiny, N., Mustafa, A., Yousef, A. Association of Human Beta – Defensin 1 Gene Polymorphisms with Alopecia Areata Patients. EKB Journal Management System, 2020; 5(Issue 1 part (1)): 53-56. doi: 10.21608/bjas.2020.135746

Association of Human Beta – Defensin 1 Gene Polymorphisms with Alopecia Areata Patients

Benha Journal of Applied Sciences
Article 7, Volume 5, Issue 1 part (1), January 2020, Page 53-56  XML PDF (675.3 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2020.135746
View on SCiNiTO View on SCiNiTO
Authors
A.A. Ibrahim1; N.F. Alhusseiny2; A.I. Mustafa1; A.S. Yousef1
1Dermatology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
2Medical Biochemistry and Molecular Biology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
Abstract
Alopecia areata (AA) is a common disease with an incidence of 2-3% among the dermatoses and 0.1% in the population at large. This disorder occurs in both sexes, at all ages, and is characterized by the sudden appearance of areas of hair loss on the scalp and other hair bearing areas. Various factors, including immunologic and endocrine abnormalities, genetic factors, infections, and psychological/ psychiatric disturbances, have been claimed to play a role in its etiopathogenesis. The aim of this study is to investigate the association between DEFB1 polymorphism and AA pathogenesis. This study was conducted on fifty patients with alopecia areata (Group A) and fifty age and sex matched apparently healthy subjects as a control group (Group B). Patients were selected from the Dermatology outpatient clinic of Benha University Hospital. Linear regression analysis was conducted for prediction of more severe AA; using age, gender, family history, AID, previous episodes, previous treatment, and rs1800972 genotypes as covariates. Rs1800972 (CG+GG) were considered as predictor of more severe AA (p < 0.001). Our study results support the associations of susceptibility with AA among patients with the DEFB1 rs1800972 genotypes. It appears that DEFB1 gene polymorphisms may modulate AA risk. So, CG, GG, genotypes and G allele were considered as predictor of AA susceptibility and severity.
Keywords
AA; AID; DEFB1 and CG
Statistics
Article View: 120
PDF Download: 336