ASSOCIATION BETWEEN GENETIC VARIANTS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF THE DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASE 1 (DDR1) A/C (RS 2267641) AND GRANZYME B (GZMB) C/T (RS8192917) GENES IN VITILIGO | ||||
The Egyptian Journal of Biochemistry and Molecular Biology | ||||
Article 1, Volume 38, Issue 1, 2020, Page 1-18 PDF (900.86 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejb.2020.136524 | ||||
View on SCiNiTO | ||||
Authors | ||||
Amany Saleh1; Wafaa Shehata2; Mohammed Elhelbawy3; Nesreen Elhelbawy* 4 | ||||
1medical biochemistry and molecular biology,faculty of medicine,menoufia university,shebin elkom,egypt. | ||||
2,2Dermatology, Andrology & Sexually Transmitted Diseases (STDs), Faculty of Medicine, Menoufia University | ||||
3Clinical Pathology Departments, Faculty of Medicine, Menoufia University | ||||
4Medical Biochemistry & Molecular Biology, Faculty of Medicine, Menoufia University | ||||
Abstract | ||||
Vitiligo manifests as advanced loss of melanocytes with reduced cellular adhesion. Discoidin Domain Receptor Tyrosine kinase1 (DDR1) is a main element affecting cellular adhesiveness associated with vitiligo. Granzyme B (GZMB) has significant role in cytotoxic T-cell induced apoptosis. This study aimed to evaluate the association between genetic variants of single nucleotide polymorphisms of DDR1 A/C (rs 2267641) and GZMB C/T (rs8192917) and the risk of developing vitiligo. The genotypes were investigated using allele discrimination assay comparing 120 patients having non-segmental vitiligo and 100 age and gender matched healthy individuals. We detected a significant prevalence of the CC genotype and C allele of both DDR1 and GZMB polymorphisms in vitiligo patients with early onset and progressive course compared to controls. Our results concluded that DDR1 A/C (rs 2267641) and GZMB C/T (rs8192917) polymorphisms may be risk factors for vitiligo. | ||||
Keywords | ||||
Vitiligo; polymorphism; DDR1; GZMB | ||||
Statistics Article View: 317 PDF Download: 288 |
||||