Serum Fatty Acid Binding Protein 4 in Patients with Androgenetic Alopecia
El-Taweel, A., Mustafa, A., Abd El-Halim, W., Abdel-Fattah, S. (2020). Serum Fatty Acid Binding Protein 4 in Patients with Androgenetic Alopecia. EKB Journal Management System, 5(Issue 5 part (2)), 279-281. doi: 10.21608/bjas.2020.136700
A.I. El-Taweel; A. I. Mustafa; W.A. Abd El-Halim; S.A. Abdel-Fattah. "Serum Fatty Acid Binding Protein 4 in Patients with Androgenetic Alopecia". EKB Journal Management System, 5, Issue 5 part (2), 2020, 279-281. doi: 10.21608/bjas.2020.136700
El-Taweel, A., Mustafa, A., Abd El-Halim, W., Abdel-Fattah, S. (2020). 'Serum Fatty Acid Binding Protein 4 in Patients with Androgenetic Alopecia', EKB Journal Management System, 5(Issue 5 part (2)), pp. 279-281. doi: 10.21608/bjas.2020.136700
El-Taweel, A., Mustafa, A., Abd El-Halim, W., Abdel-Fattah, S. Serum Fatty Acid Binding Protein 4 in Patients with Androgenetic Alopecia. EKB Journal Management System, 2020; 5(Issue 5 part (2)): 279-281. doi: 10.21608/bjas.2020.136700

Serum Fatty Acid Binding Protein 4 in Patients with Androgenetic Alopecia

Benha Journal of Applied Sciences
Article 13, Volume 5, Issue 5 part (2), August 2020, Page 279-281  XML PDF (569.1 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2020.136700
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Authors
A.I. El-Taweel1; A. I. Mustafa1; W.A. Abd El-Halim2; S.A. Abdel-Fattah3
1Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
2Clinical and Chemical Pathology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
3Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Zagazig Univ., Zagazig, Egypt
Abstract
Androgenetic alopecia (AGA) is the most common cause of hair loss. Adipocyte fatty acid-binding protein (FABP4), also termed adipocyte protein 2 (aP2), is an adipokine synthesized and released predominantly from adipocytes and, to a lesser extent, produced in macrophages and endothelial cells. Elevated levels of FABP4 are closely linked with the development of obesity, DM, hypertension and atherosclerosis. we aimed to assess the level of serum FABP4 in patients with AGA. This case-control study was conducted on thirty male patients and twenty female patients complaining of androgenetic alopecia, and thirty age and BMI matched healthy volunteers. Patients were recruited from outpatient clinic of Dermatology, Venereology and Andrology Department of Benha University Hospitals during the period from December 2017 to June 2018.All participants were tested for determination of fatty acid binding protein 4 serum levels. AGA patients showed significantly higher FABP4 levels when compared to controls. Serum FABP4 level was significantly higher in AGA patients than in control group so it might play a role in androgenetic alopecia pathogenesis. Moreover, it could be considered a biomarker for early diagnosis of the disease with high sensitivity, specificity and accuracy rate.
Keywords
Androgenetic alopecia; FABP4; Diagnosis
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