Anti-Cancer Activity of the Rubus idaeus Extracts Against HepG2 and L20B Cell Lines Using Tissue Culture Technique | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Article 3, Volume 7, Issue 2, December 2015, Page 19-23 PDF (388.71 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2015.13687 | ||||
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| Authors | ||||
| Nahla K. Assad1; Batool I. Dheeba2; Farooq I. Mohammad3; Abdullah I. Hamad1 | ||||
| 1College of Dentisty, Tikreet University | ||||
| 2Biology Department, College of Education, Iraqia University | ||||
| 3Biotechnology Research Center, Al- Nahrain University | ||||
| Abstract | ||||
| The extracts were prepared from ripe blackberries. The extracts were tested against the human hepatocellular carcinoma cell line, HepG2, and the mouse cell line L20B using a neutral red assay. The extracts showed a clear inhibition rate, in a dose dependent manner in both cell lines. In addition, the inhibition rate was significantly higher (P < 0.05) for alcoholic extracts in both cell lines compared to aqueous extracts. The results clearly show that Rubus idaeus fruit extracts have potent cytotoxic and cytostatic effects on both cell lines. On the basis of these results, we can conclude that Rubus idaeus has a strong cytotoxic effect on both human and mouse cancerous cells. | ||||
| Keywords | ||||
| Rubus idaeus; Cytotoxic activity anti-cancer HepG2 L20B | ||||
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