Intralesional Injection of 5-Fluorouracil in Verruca Vulgaris: Immunohistochemical and Clinical Study
El-Rifae, A., Agina, H., Akl, E., Dawod, A. (2020). Intralesional Injection of 5-Fluorouracil in Verruca Vulgaris: Immunohistochemical and Clinical Study. EKB Journal Management System, 5(Issue 6 part (2)), 199-204. doi: 10.21608/bjas.2020.137149
A.A. El-Rifae; H.A. Agina; E.M. Akl; A.N. Dawod. "Intralesional Injection of 5-Fluorouracil in Verruca Vulgaris: Immunohistochemical and Clinical Study". EKB Journal Management System, 5, Issue 6 part (2), 2020, 199-204. doi: 10.21608/bjas.2020.137149
El-Rifae, A., Agina, H., Akl, E., Dawod, A. (2020). 'Intralesional Injection of 5-Fluorouracil in Verruca Vulgaris: Immunohistochemical and Clinical Study', EKB Journal Management System, 5(Issue 6 part (2)), pp. 199-204. doi: 10.21608/bjas.2020.137149
El-Rifae, A., Agina, H., Akl, E., Dawod, A. Intralesional Injection of 5-Fluorouracil in Verruca Vulgaris: Immunohistochemical and Clinical Study. EKB Journal Management System, 2020; 5(Issue 6 part (2)): 199-204. doi: 10.21608/bjas.2020.137149

Intralesional Injection of 5-Fluorouracil in Verruca Vulgaris: Immunohistochemical and Clinical Study

Benha Journal of Applied Sciences
Article 7, Volume 5, Issue 6 part (2), September 2020, Page 199-204  XML PDF (487.34 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2020.137149
View on SCiNiTO View on SCiNiTO
Authors
A.A. El-Rifae1; H.A. Agina1; E.M. Akl2; A.N. Dawod1
1Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
2Pathology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
Abstract
VV speak to a problematic remedial issue for the two patients and doctors. In this investigation, we planned to assess the clinical adequacy and wellbeing of intralesional 5-fu in the treatment of headstrong vv in grown-up patients. It included 60 patients. Subjects and techniques: The patients were isolated into 2 gathering, Group I: As a benchmark group of 10 solid volunteers were biopsied from typical non sun uncovered skin utilizing 4-6mm punch biopsies and Group II: 50 patients with vv exposed to: Group IIa: 15 vv were biopsied before infusion of 5-fu for histological and immunohistochemical examination.Group IIb: 15 vv were biopsied after infusion of 5-fu after 3,4and 7days for histological and immunohistochemical assessment. Infusions were rehashed like clockwork, most extreme for six infusions. Results : caspase-3 was somewhat communicated in completely contemplated instances of typical skin. Caspase-3 was communicated in just 40% of vv which have been biopsied before 5-fu infusion however after infusion the exepression expanded to 86.7%. The previously mentioned findings may reveal insight into the counter apoptotic physiologic part of caspase-3 in typical skin. Caspase-3 over articulation ater 5-fu infusion proposes a likely function of 5-fu on enlistment of apoptosisConclusion: 5-fu is a promising compelling and safe methodology for the treatment of different vv with high freedom rate, gentle and transient unfriendly impacts.
Statistics
Article View: 149
PDF Download: 637