Assessment of Neural Precursor Cell Expressed Developmentally Down- Regulated Protein 4 Gene Transcript Variant 3 Expression and Insulin- Like Gross Factor -1 in Keloid Tissue | ||||
Benha Journal of Applied Sciences | ||||
Article 15, Volume 5, Issue 6 part (2), September 2020, Page 253-255 PDF (806.91 K) | ||||
Document Type: Original Research Papers | ||||
DOI: 10.21608/bjas.2020.137172 | ||||
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Authors | ||||
A.M. Alrefai1; N.E. Srour1; N.F. Al-Husseini2; M.S. Abd-Elsayed1 | ||||
1Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||||
2Biochemistry and Molecular Biology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||||
Abstract | ||||
Keloids are considered as favorable fibro-proliferative skin tumors developing past the site of the first dermal injury. Neural forerunner cell communicated formatively down-controlled protein 4 (NEDD4) is an E3 ubiquitin ligase catalyst that objectives proteins for ubiquitination. In this investigation, it was intended to survey Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4 Gene Transcript Variant 3(NEDD4 TV3) and Insulin-like Gross Factor - 1 (IGF-1) in patients with dynamic keloid ≤ 6months length. The examination included 40 patients of keloids and 20 subjects of coordinated age, sex and weight file (BMI). There was critical positive relationship between's NEDD4TV-3 and IGF quality articulation. This information add novel angles to the part of NEDD4 TV3 in the advancement of keloid. | ||||
Keywords | ||||
Keloid; NEDD4 TV3 | ||||
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