Sirt-1 as A Predictive Marker of Metabolic Syndrome in Psoriasis Patients | ||||
Benha Journal of Applied Sciences | ||||
Article 4, Volume 5, Issue 7 part (1) - (2), October 2020, Page 15-17 PDF (680.55 K) | ||||
Document Type: Original Research Papers | ||||
DOI: 10.21608/bjas.2020.137383 | ||||
View on SCiNiTO | ||||
Authors | ||||
H.H. sabry1; A.M. Hamed1; A.A. El Fallah2; A.R. Ghonamey3 | ||||
1Dermatology,Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||||
2Clinical and Chemical Pathology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||||
3Dermatology,Venereology and Andrology Dept., Al.Houd Almarsoud hospital , Cairo , Egypt | ||||
Abstract | ||||
Psoriasis affects mainly skin, nails and joint and is characterized by the presence of sharply demarcated, red plaques with adherent silvery white scales and a tendency for symmetrical distribution over the body. Psoriasis can be provoked by external and internal triggers, including mild trauma, sunburn, infections, systemic drugs and stress. There is a strong positive association between psoriasis and known risk factors including central obesity, insulin resistance and dyslipidemia. Sirt-1 is a NAD+-dependent deacetylase involved in the regulation of a myriad of cellular processes including mitochondrial biogenesis, genomic stability, cellular senescence and apoptosisAim: The aim of this study was to assess serum levels of sirt-1 in psoriasis patients and correlate their levels with the severity of the disease.. Method: This present study included: Patient group (group 1) included 25 psoriasis patients. In addition, 15 apparently healthy, age and sex matched individuals included as a control group (Group 2). All were investigated for serum sirt 1 level and compared. Serum Sirt 1 were estimated using commercially available ELISA kits. Conclusion: From the results of present study, it is concluded that sirt 1levels are lower in psoriasis patients not corrospnding to the disease severity. | ||||
Keywords | ||||
Psoriasis; Metabolic syndrome; Sirt 1 | ||||
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