Formulation factors of starch-based nanosystems preparation and their pharmaceutical application
Gardouh, A., Srag El-Din, A., Moustafa, Y., Gad, S. (2021). Formulation factors of starch-based nanosystems preparation and their pharmaceutical application. EKB Journal Management System, 5(Pharmacology-Pharmaceutics), 28-39. doi: 10.21608/rpbs.2020.51097.1080
Ahmed Gardouh; Ahmed S.G. Srag El-Din; Yasser Moustafa; Shadeed Gad. "Formulation factors of starch-based nanosystems preparation and their pharmaceutical application". EKB Journal Management System, 5, Pharmacology-Pharmaceutics, 2021, 28-39. doi: 10.21608/rpbs.2020.51097.1080
Gardouh, A., Srag El-Din, A., Moustafa, Y., Gad, S. (2021). 'Formulation factors of starch-based nanosystems preparation and their pharmaceutical application', EKB Journal Management System, 5(Pharmacology-Pharmaceutics), pp. 28-39. doi: 10.21608/rpbs.2020.51097.1080
Gardouh, A., Srag El-Din, A., Moustafa, Y., Gad, S. Formulation factors of starch-based nanosystems preparation and their pharmaceutical application. EKB Journal Management System, 2021; 5(Pharmacology-Pharmaceutics): 28-39. doi: 10.21608/rpbs.2020.51097.1080

Formulation factors of starch-based nanosystems preparation and their pharmaceutical application

Records of Pharmaceutical and Biomedical Sciences
Article 4, Volume 5, Pharmacology-Pharmaceutics, January 2021, Page 28-39  XML PDF (664.15 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2020.51097.1080
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Authors
Ahmed Gardouhorcid 1; Ahmed S.G. Srag El-Din email orcid 2; Yasser Moustafaorcid 3; Shadeed Gadorcid 4
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. Department of Pharmaceutical Sciences, Faculty of Pharmacy, Jadara University, Irbid 221110, Jordan.
2pharmaceutics department, faculty of pharmacy delta university for science and technology
3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
4Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Abstract
Starch-based nanosystems are considered a talented nanocarrier for drug delivery owing to their small particle size, biodegradability, and biocompatibilities. Starch-based nanosystems showed enhancement in biological activity, solubility, entrapment efficiency, and in-vitro release of several drugs. Starch-based nanosystems are categorized into two types; starch nanocrystals and starch nanoparticles. The difference between starch nanocrystals and starch nanoparticles will be summarized. Numerous techniques are employed to formulate starch-based nanosystems including chemical and physical methods. This review summarizes the existing knowledge on; a number of techniques used to formulate starch-based nanosystems, factors affecting each technique, and the advantages of combining both physical and chemical methods on the formulation time and physicochemical properties of the starch-based nanosystems. Besides, most innovative information regarding starch-based nanosystems modification on increasing entrapment efficiency will be discussed. Furthermore, applying starch-based nanosystems as effective drug delivery nanocarriers for delivering drugs and bioactive elements to improve their bioavailability will be abridged in this review.
Keywords
Starch-based nanosystems; acid hydrolysis; nanoprecipitation; ultrasound; high-pressure homogenizer
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