Polymorphism of 11 β-Hydroxysteroid Dehydrogenase Type 1 Gene in Hypertensive Patients
Mohamed, R., Elzaiat, A., Elfeky, H., Al-Karamany, A. (2022). Polymorphism of 11 β-Hydroxysteroid Dehydrogenase Type 1 Gene in Hypertensive Patients. EKB Journal Management System, 28(4), 728-733. doi: 10.21608/zumj.2021.42702.1942
Randa hussiny Mohamed; Ahmed Mohamed Elzaiat; Hoda Kamal Elfeky; Amira Saber Al-Karamany. "Polymorphism of 11 β-Hydroxysteroid Dehydrogenase Type 1 Gene in Hypertensive Patients". EKB Journal Management System, 28, 4, 2022, 728-733. doi: 10.21608/zumj.2021.42702.1942
Mohamed, R., Elzaiat, A., Elfeky, H., Al-Karamany, A. (2022). 'Polymorphism of 11 β-Hydroxysteroid Dehydrogenase Type 1 Gene in Hypertensive Patients', EKB Journal Management System, 28(4), pp. 728-733. doi: 10.21608/zumj.2021.42702.1942
Mohamed, R., Elzaiat, A., Elfeky, H., Al-Karamany, A. Polymorphism of 11 β-Hydroxysteroid Dehydrogenase Type 1 Gene in Hypertensive Patients. EKB Journal Management System, 2022; 28(4): 728-733. doi: 10.21608/zumj.2021.42702.1942

Polymorphism of 11 β-Hydroxysteroid Dehydrogenase Type 1 Gene in Hypertensive Patients

Zagazig University Medical Journal
Article 15, Volume 28, Issue 4, July 2022, Page 728-733  XML PDF (352.86 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.42702.1942
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Authors
Randa hussiny Mohamed1; Ahmed Mohamed Elzaiatorcid 2; Hoda Kamal Elfeky email 3; Amira Saber Al-Karamany4
1Medical Biochemistry Faculty of Medicine - Zagazig University ,Zagazig city,Egypt
2Cardiology Faculty of Medicine - Zagazig University, Zagazig city,Egypt
3Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig city, Egypt
4Medical Biochemistry Faculty of Medicine - Zagazig University,Zagazig city,Egypt
Abstract
Background: Essential hypertension (EH) is the most well-known cardiovascular illness. It is estimated that (30% - 40%) of blood pressure (BP) is caused by genetic factor. Objectives: to investigate the relation between 11 beta hydroxysteroid dehydrogenase type 1) 11β-HSD1 (gene polymorphism and EH in patients attending Zagazig University Hospitals. Methods: Thirty-one patients having EH and the control group of thirty-one apparently healthy individuals. 11β-HSD1 gene polymorphism (rs45487298) was analyzed by restriction fragment length polymorphism reaction. Results: we found that A allele was significantly higher in hypertension (HTN) group and Subjects carrying A allele had a higher incidence to have HTN (OR = 2.5, 95 % CI = 1.04–5.8 and P = 0.04). Levels of TG, and total cholesterol, were significantly higher and levels of HDL cholesterol were significantly lower in A/A than in wtwt genotype. Also A allele and triglycerides are independent risk factor for EH development. Conclusion: there was a significant relation between 11β-HSD1 gene polymorphism and EH.
Keywords
Essential hypertension; 11β-HSD1 gene; Polymorphisms; cardiovascular risk factors; genotypes
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