1.4-Arylation of β-(4-acetylaminobenzoyl)acrylic Acid with Activated Aromatic Hydrocarbons under Friedel-Crafts Conditions and Some Studies with the Products | ||||
| Egyptian Journal of Chemistry | ||||
| Article 5, Volume 54, Issue 1, February 2012, Page 69-79 PDF (465.46 K) | ||||
| DOI: 10.21608/ejchem.2011.1380 | ||||
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| Abstract | ||||
| THE BEHAVIUOR of 3-(4-acetylaminobenzoyl) prop-2-enoic acid 1 with m-xylene and\or p-xylene under Friedel-Craft,s reaction conditions yielded 2- ( 2,4-Dimethyl and/or 2,5-dimethyl ) phenyl-3-(4-acetylaminobenzoyl)propanoic acids (2a,b) and thia-Micheal of acid 1 afforded 2- phenyl sulfanyl-3-(4-acetylamino benzoyl propanoic acid (3). Interaction of acids 2,3 with N2H4 , AC2O, NH2OH.HCl and PhNHNH2, yielded pyridazinone 4 , Furanone 5 1, 2oxazine 6 and 2-phenyl pyridazinone derivatives, respectively. Treatment of pyridazinone 4 with different interesting alkyl halides afforded the pyridazine derivatives 8 . | ||||
| Keywords | ||||
| 3-Aroyl prop-2-enoic acid. Pyridazinone. Furanone; oxazinone and Alkyl pyridazine | ||||
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