Effect of combined Hesperidin, Piperine, Bee venom and Tamoxifen on oxidative stress and hepato-nephrotoxicity amelioration against breast cancer in rats
Khamis, A., Ali, E., Abd El-Moneim, M., Salim, E. (2018). Effect of combined Hesperidin, Piperine, Bee venom and Tamoxifen on oxidative stress and hepato-nephrotoxicity amelioration against breast cancer in rats. EKB Journal Management System, 39(1), 28-38. doi: 10.21608/djs.2018.138904
Abeer A. Khamis; Ehab M. Ali; Mohamed A. Abd El-Moneim; Elsayed I. Salim. "Effect of combined Hesperidin, Piperine, Bee venom and Tamoxifen on oxidative stress and hepato-nephrotoxicity amelioration against breast cancer in rats". EKB Journal Management System, 39, 1, 2018, 28-38. doi: 10.21608/djs.2018.138904
Khamis, A., Ali, E., Abd El-Moneim, M., Salim, E. (2018). 'Effect of combined Hesperidin, Piperine, Bee venom and Tamoxifen on oxidative stress and hepato-nephrotoxicity amelioration against breast cancer in rats', EKB Journal Management System, 39(1), pp. 28-38. doi: 10.21608/djs.2018.138904
Khamis, A., Ali, E., Abd El-Moneim, M., Salim, E. Effect of combined Hesperidin, Piperine, Bee venom and Tamoxifen on oxidative stress and hepato-nephrotoxicity amelioration against breast cancer in rats. EKB Journal Management System, 2018; 39(1): 28-38. doi: 10.21608/djs.2018.138904

Effect of combined Hesperidin, Piperine, Bee venom and Tamoxifen on oxidative stress and hepato-nephrotoxicity amelioration against breast cancer in rats

Delta Journal of Science
Article 5, Volume 39, Issue 1, June 2018, Page 28-38  XML PDF (1004.22 K)
Document Type: Research and Reference
DOI: 10.21608/djs.2018.138904
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Authors
Abeer A. Khamis1; Ehab M. Ali2; Mohamed A. Abd El-Moneim3; Elsayed I. Salim4
1Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt
2Biochemistry Division, Chemistry Department, Faculty of Science, King Abdul Aziz University KAU, Jeddah, Saudi Arabia
3Biochemistry Department, Faculty of Dentistry, Sinai University, Al-Arish, North Sinai, Egypt
4Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
Abstract
Breast cancer is the most commonly diagnosed cancer and the major cause of cancer-related death among females. Studies on natural compounds used alone or in combination with chemotherapeutic agents proved their efficacy to treat and prevent cancer. Hesperidin, Piperine, and Bee venom displayed anti-oxidant and anti‑cancer activity against various types of cancers and cell lines and can be used in combination with Tamoxifen with the aim to decrease cytotoxicity profile. In-vivo study of Piperine (Pip), Bee venom (BV) and hesperidin (Hes) as a single treatment or in combination with/without tamoxifen indicated low hepato-nephrotoxicity and hepato-nephroprotective against tamoxifen-treated and untreated xenograft MCF-7 induced breast cancer. Serum ALT, AST, ALP activities and creatinine, and urea level were elevated. MDA level was increased with a marked reduction in SOD activity in the untreated xenograft MCF-7 induced breast cancer. Treatments for these natural products improve these parameters. It could be concluded that alone or in combination with/ without Tamoxifen clarified a modulatory role against breast cancer.
Keywords
Breast cancer; Tamoxifen; Hesperidin; Piperine; Bee venom; Hepato-nephrotoxicity
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