Serum Peptidyl Argenine Deiminase - 4 (PADI4) Antibodies in Rheumatoid Arthritis and their Correlation with Disease Activity
Amin, A., Elgawish, M., Esh, A., Makram, W. (2023). Serum Peptidyl Argenine Deiminase - 4 (PADI4) Antibodies in Rheumatoid Arthritis and their Correlation with Disease Activity. EKB Journal Management System, 29(2.1), 80-86. doi: 10.21608/zumj.2021.48120.1989
Aya Akmal Amin; Mohammad Hassan Elgawish; Asmaa Mohamed Esh; Wafaa K. Makram. "Serum Peptidyl Argenine Deiminase - 4 (PADI4) Antibodies in Rheumatoid Arthritis and their Correlation with Disease Activity". EKB Journal Management System, 29, 2.1, 2023, 80-86. doi: 10.21608/zumj.2021.48120.1989
Amin, A., Elgawish, M., Esh, A., Makram, W. (2023). 'Serum Peptidyl Argenine Deiminase - 4 (PADI4) Antibodies in Rheumatoid Arthritis and their Correlation with Disease Activity', EKB Journal Management System, 29(2.1), pp. 80-86. doi: 10.21608/zumj.2021.48120.1989
Amin, A., Elgawish, M., Esh, A., Makram, W. Serum Peptidyl Argenine Deiminase - 4 (PADI4) Antibodies in Rheumatoid Arthritis and their Correlation with Disease Activity. EKB Journal Management System, 2023; 29(2.1): 80-86. doi: 10.21608/zumj.2021.48120.1989

Serum Peptidyl Argenine Deiminase - 4 (PADI4) Antibodies in Rheumatoid Arthritis and their Correlation with Disease Activity

Zagazig University Medical Journal
Article 13, Volume 29, Issue 2.1, March and April 2023, Page 80-86  XML PDF (276.66 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.48120.1989
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Authors
Aya Akmal Amin email 1; Mohammad Hassan Elgawish2; Asmaa Mohamed Esh3; Wafaa K. Makramorcid 2
1Department of Physical Medicine Rheumatology and Rehabilitation, Faculty of Medicine – Zagazig University, Egypt.
2Department of Physical Medicine Rheumatology and Rehabilitation, Faculty of Medicine – Zagazig University, Egypt.
3Department of Clinical Pathology, Faculty of Medicine Zagazig University, Egypt.
Abstract
Background: Autoantibodies are the hallmark of autoimmune diseases. For Rheumatoid arthritis (RA), they represent equipment for prognosis, detection and analysis of the disease. Several serological markers have recently emerged. For instance, serum Anti-PADI4 that is the enzyme that causes citrullination of proteins leading to autoantibodies production. The goal of this work was to assess the role of peptidyl arginine deiminase type 4 (PADI4) in diagnosis of rheumatoid arthritis and association of its serum level with disease activity. Methods: A case-control study involving 58 subjects, 29 patients with RA and 29 healthy controls matched in age and sex, was carried out at Department of Rheumatology and Rehabilitation, Zagazig University Hospitals. Detailed history taking, clinical examination and assessment of disease activity using: - DAS-28, modified HAQ, CRP, ESR and PGA. Serum Anti-PADI4 was measured in RA patients and healthy controls using quantitative ELISA technique. Results: Statistical analysis of the obtained clinical and laboratory data showed a significant elevation of serum Anti-PADI4 in RA patients 15.39±8.89 ng/ml when compared to controls 6.32±10.3* ng/ml (P
Keywords
Peptidyl Argenine Deiminase-4; Rheumatoid arthritis; DAS28 or disease activity; diagnostic
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