Validated Spectrophotometric method for analysis of Dipyridamole and Lamivudine using eosin Y
Barghash, S., Abd El-Razeq, S., El -Awady, M., Belal, F. (2021). Validated Spectrophotometric method for analysis of Dipyridamole and Lamivudine using eosin Y. EKB Journal Management System, 1(1), 87-96. doi: 10.21608/aijpms.2021.52761.1016
Sona Soliman Barghash; Sawsan Abd El-Razeq; Mohamed El -Awady; Fathalla Belal. "Validated Spectrophotometric method for analysis of Dipyridamole and Lamivudine using eosin Y". EKB Journal Management System, 1, 1, 2021, 87-96. doi: 10.21608/aijpms.2021.52761.1016
Barghash, S., Abd El-Razeq, S., El -Awady, M., Belal, F. (2021). 'Validated Spectrophotometric method for analysis of Dipyridamole and Lamivudine using eosin Y', EKB Journal Management System, 1(1), pp. 87-96. doi: 10.21608/aijpms.2021.52761.1016
Barghash, S., Abd El-Razeq, S., El -Awady, M., Belal, F. Validated Spectrophotometric method for analysis of Dipyridamole and Lamivudine using eosin Y. EKB Journal Management System, 2021; 1(1): 87-96. doi: 10.21608/aijpms.2021.52761.1016

Validated Spectrophotometric method for analysis of Dipyridamole and Lamivudine using eosin Y

Azhar International Journal of Pharmaceutical and Medical Sciences
Article 9, Volume 1, Issue 1, January 2021, Page 87-96  XML PDF (475.32 K)
Document Type: Original research articles
DOI: 10.21608/aijpms.2021.52761.1016
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Authors
Sona Soliman Barghash email 1; Sawsan Abd El-Razeqorcid 2; Mohamed El -Awady3; Fathalla Belal4
1Pharmaceutical Analytical Chemistry ,Faculty of Pharmacy,Al-Azhar University ,Cairo,Egypt
2Analytical Chemistry,Faculty of Pharmacy,Al-Azhar University,Cairo,Egypt
3Analytical Chemistry,Faculty of Pharmacy,Mansoura University,Mansoura, Egypt
4Analytical Chemistry,Faculty of Pharmacy,Mansoura University,Mansoura,Egypt
Abstract
Validated, accurate, simple and reliable spectrophotometric method was described for the assay of dipyridamole and lamivudine in their different dosage forms. The suggested method depended on a binary reddish orange coloured complexformation between eosin Y and each one of the two analytes in presence of carboxy methyl cellulose and aqueous buffered medium for dipyridamole and lamivudine, respectively at pH 3.7. The coloured binary complexes exhibited maximum absorbance at 554.0 nm for dipyridamole and lamivudine. The absorbance concentration graphs were linear over ranges of (1.0-10.0 μg/mL) and (2.0-20.0 μg/mL), with lower detection limits of 0.27 μg/mL and 0.46 μg/mL and lower quantitation limits of 0.82 μg/mL and 1.40 μg/mL for dipyridamole and lamivudine, respectively. The developed method was applicable to the assay of dipyridamole and lamivudine in their different dosage forms, and the obtained results were in acceptable agreement with all those provided by reference methods. The present method is appropriate for the assay of the two drugs on account of its cost effectiveness, simplicity and rapidity
Keywords
spectrophotometric; dipyridamole; lamivudine; eosin Y; dosage forms
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