CURATIVE EFFECTS OF GUM ARABIC AND BOSWELLIA SPECIES ON ACUTE RENAL FAILURE IN EXPERIMENTAL RATS
Mohamed, R., Tawfik, M., Ibrahim, H., Tag El-Din, M., Hamada, A. (2018). CURATIVE EFFECTS OF GUM ARABIC AND BOSWELLIA SPECIES ON ACUTE RENAL FAILURE IN EXPERIMENTAL RATS. EKB Journal Management System, 26(1), 243-253. doi: 10.21608/ajs.2018.13917
Reda N. Mohamed; M. F. Tawfik; Hemmat A. Ibrahim; M. A. Tag El-Din; A. M. Hamada. "CURATIVE EFFECTS OF GUM ARABIC AND BOSWELLIA SPECIES ON ACUTE RENAL FAILURE IN EXPERIMENTAL RATS". EKB Journal Management System, 26, 1, 2018, 243-253. doi: 10.21608/ajs.2018.13917
Mohamed, R., Tawfik, M., Ibrahim, H., Tag El-Din, M., Hamada, A. (2018). 'CURATIVE EFFECTS OF GUM ARABIC AND BOSWELLIA SPECIES ON ACUTE RENAL FAILURE IN EXPERIMENTAL RATS', EKB Journal Management System, 26(1), pp. 243-253. doi: 10.21608/ajs.2018.13917
Mohamed, R., Tawfik, M., Ibrahim, H., Tag El-Din, M., Hamada, A. CURATIVE EFFECTS OF GUM ARABIC AND BOSWELLIA SPECIES ON ACUTE RENAL FAILURE IN EXPERIMENTAL RATS. EKB Journal Management System, 2018; 26(1): 243-253. doi: 10.21608/ajs.2018.13917

CURATIVE EFFECTS OF GUM ARABIC AND BOSWELLIA SPECIES ON ACUTE RENAL FAILURE IN EXPERIMENTAL RATS

Arab Universities Journal of Agricultural Sciences
Article 18, Volume 26, Issue 1, March 2018, Page 243-253  XML PDF (377.98 K)
Document Type: Original Article
DOI: 10.21608/ajs.2018.13917
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Authors
Reda N. Mohamed* 1; M. F. Tawfik1; Hemmat A. Ibrahim1; M. A. Tag El-Din1; A. M. Hamada2
1Agric. Biochemistry Dept., Fac. of Agric., Ain Shams Univ., Cairo, Egypt
2Clinical Pathology Dept., Fac. of Medicine, Ain Shams Univ., Cairo, Egypt
Abstract
Acute renal failure (ARF) was induced by glycerol or paracetamol in experimental rats to evaluate the curative effects of gum Arabic and Boswellia sp. through different blood biochemical assays and hematological analyses. Results revealed presence of significant (P<0.05) increases in the levels of urea, creatinine, potassium (K+), sodium (Na+), chloride (Cl-) and blood acidity (H+), and significant (P<0.05) decreases in the levels of calcium (Ca+2) and bicarbonate (HCO3-) in the rats treated only with glycerol or paracetamol in the positive control groups compared to the negative control group. These results indicated that glycerol or paracetamol caused ARF in these groups of rats whereas the blood analyses illustrated ARF symptoms such as increasing of urea and creatinine, hyperkalemia, hypocalcemia, hypoglycemia, blood acidosis and anemia occurring in the positive control groups.  The blood analyses also illustrated recovery of these symptoms in the treated rats with gum Arabic and Boswellia sp. in drinking water (10% w/v) for 30 days. This indicated the curative effects of gum Arabic and Boswellia sp. against ARF induced by glycerol or paracetamol as evidenced by restoring the kidney function tests such as urea, creatinine, blood electrolytes and other parameters like serum glucose, proteins and hematological indices to their normal values during the experiment period. The therapeutic effects of both plants against ARF may be due to their antioxidant and/or anti-inflammatory activity.  
Keywords
acute renal failure; Boswellia sp; glycerol; Gum Arabic; Paracetamol; Rats
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