Modification of Chitosan and Polymethyl methacrylate with 5-Phenyl-1,3,4-oxadiazole Derivatives and their Antifungal Activity | ||||
Delta Journal of Science | ||||
Article 7, Volume 40, Issue 1, June 2019, Page 59-70 PDF (1.61 MB) | ||||
Document Type: Research and Reference | ||||
DOI: 10.21608/djs.2019.139198 | ||||
View on SCiNiTO | ||||
Authors | ||||
El-Refaie Kenawy1; Ahmed A. Elbarbary2; E. G. I. Hamada* 3 | ||||
1Chemistry Department, Faculty of Science, Tanta University, Egypt. 2Plant Protection | ||||
2Chemistry Department, Faculty of Science, Tanta University, Egypt | ||||
3Plant Protection Institute, Agriculture Research Center (A.R.C), Egypt | ||||
Abstract | ||||
Functionalization of chitosan (Cs) and modified polymethylmethacrylate (PMMA) with 5-phenyl- 1,3,4-oxadiazole derivatives was achieved for biological applications. Reaction of 5-phenyl-1,3,4- oxadiazole-2-thiol (1) with both Cs and functionalized PMMA with 1,2-ethylenenediamine afforded the grafted polymers 2 and 3, respectively. Additionally, reaction of compound 1 with ethylchloroformate furnished O-ethyl S-(5-phenyl-1,3,4-oxadiazol-2-yl) carbonothioate (4). Similarly, grafting of compound 4 with both Cs and functionalized PMMA yielded polymers 5 and 6, respectively. Some of the grafted polymers were characterized using Fourier transform infrared (FT-IR). The thermal properties of these polymers were investigated using thermo gravimetric analysis (TGA) which displayed the first degradation of water and 5-phenyl-1,3,4-oxadiazole derivatives followed by the degradation of the main Cs and PMMA chains. X-ray diffraction (XRD) explained the crystal structure of the functionalized polymers with the appearance of Cs and PMMA peaks and the new peaks that referred to oxadiazole moieties. The biological activity of these polymers was investigated as antifungal agents where compound 1 showed the highest antifungal activity. | ||||
Keywords | ||||
5-phenyl-1; 3; 4-Oxadiazole; Chitosan; Polymethylmethacrylate; Antifungal Activity | ||||
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