New Approaches for the Uses of 2-Cyanomethyl Thiazole in the Synthesis of Fused Heterocyclic Derivatives with Anti-Tumor Activities
(2011). New Approaches for the Uses of 2-Cyanomethyl Thiazole in the Synthesis of Fused Heterocyclic Derivatives with Anti-Tumor Activities. EKB Journal Management System, 54(2), 289-297. doi: 10.21608/ejchem.2011.1395
. "New Approaches for the Uses of 2-Cyanomethyl Thiazole in the Synthesis of Fused Heterocyclic Derivatives with Anti-Tumor Activities". EKB Journal Management System, 54, 2, 2011, 289-297. doi: 10.21608/ejchem.2011.1395
(2011). 'New Approaches for the Uses of 2-Cyanomethyl Thiazole in the Synthesis of Fused Heterocyclic Derivatives with Anti-Tumor Activities', EKB Journal Management System, 54(2), pp. 289-297. doi: 10.21608/ejchem.2011.1395
New Approaches for the Uses of 2-Cyanomethyl Thiazole in the Synthesis of Fused Heterocyclic Derivatives with Anti-Tumor Activities. EKB Journal Management System, 2011; 54(2): 289-297. doi: 10.21608/ejchem.2011.1395

New Approaches for the Uses of 2-Cyanomethyl Thiazole in the Synthesis of Fused Heterocyclic Derivatives with Anti-Tumor Activities

Egyptian Journal of Chemistry
Article 10, Volume 54, Issue 2, April 2012, Page 289-297  XML PDF (289.65 K)
DOI: 10.21608/ejchem.2011.1395
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Abstract
 2-(4,5-DIHYDRO-4-oxothiazol-2-yl)acetonitrile (1) reacted with 2- .......acetylcoumarin (2) to give the 2-(4,5-dihydro-4-oxothiazol-2-yl)- 3-(2-oxo-2H-chromen-3-yl)but-2-enenitrile (3). The reactivity of the latter product towards aromatic aldehydes 4a-d, cyanomethylene reagents 6a,b, aryl diazonium salts 10a-d, was studied to give products that were evaluated against the three cancer cells namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268). Some of them have high inhibitory effect towards three cell lines and compounds 14 and 16 were found to be more active than the standard on NCI-H460 and SF-268.
Keywords
thiazole; Coumarin; pyrazole; Pyridazine and Anti-tumor
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