Hepatotoxicity, anti-oxidant defence dysfunction and oxidative stress of permethrin and cypermethrin in male albino rats | ||||
Delta Journal of Science | ||||
Article 3, Volume 36, Issue 2, June 2013, Page 11-16 PDF (936.27 K) | ||||
Document Type: Research and Reference | ||||
DOI: 10.21608/djs.2013.139622 | ||||
View on SCiNiTO | ||||
Authors | ||||
Faten R. Abdel-Ghaffar1; Azza M. Mohamed2; Ibrahim A. El-Elaimy1; Mona A. Assar1 | ||||
1Department of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt. | ||||
2Department of Biochemistry, National Research Center, Dokki, Egypt. | ||||
Abstract | ||||
Pyrethroids insectecides, permethrin(PM) and cypermethrin (CM) are used on a large scale in many agricultural protection programs and may cause hazards for animal and human health. The aim of the present study was to evaluate the hepatotoxicity of these pyrethroids on male albino rats in two foldes ; oxidative stress and antioxidant defence dysfunction. Rats received 1/60 LD50 of PM (20.83 mg/kg b. wt., orally/ day, for 30 days) and CM (8.33 mg/kg b. wt., orally/ day, for 30 days).Our results showed that serum hepatic function biomarkars, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymes, recorded a highly significant (P < 0.001) elevation in both PM and CM treated groups. Various anti-oxidants; reduced glutathione, glutathione reductase, glutathione peroxidase, catalase and superoxide dismutase enzymes, recorded highly significant (P < 0.001) reductions with both PM and CM treatment. On the other hand, oxidative stress markers; xanthine oxidase (XO), lipid peroxidation (LPO) and advanced oxidation protein products (AOPPs) elevated in treated animals with PM or CM. In general, it is clear from our data that, CM is more effective than PM. This may be expected with considering the presence of an alpha-cyno substituent in CM structure which can potentaite its toxicity. | ||||
Keywords | ||||
Pyrethroids; Permethrin; Cypermethrin; Anti-oxidant defence; Oxidative stress | ||||
Statistics Article View: 76 PDF Download: 143 |
||||