Protective and curative effect of silymarin against chlorpyrifos-induced immunotoxicity in rats
El Elaimy, I., Ibrahim, H., Abdel Gafaar, F., Al-Awthan, Y. (2013). Protective and curative effect of silymarin against chlorpyrifos-induced immunotoxicity in rats. EKB Journal Management System, 36(2), 106-115. doi: 10.21608/djs.2013.139662
Ibrahim A. El Elaimy; Hany M. Ibrahim; Faten R. Abdel Gafaar; Yahya S. Al-Awthan. "Protective and curative effect of silymarin against chlorpyrifos-induced immunotoxicity in rats". EKB Journal Management System, 36, 2, 2013, 106-115. doi: 10.21608/djs.2013.139662
El Elaimy, I., Ibrahim, H., Abdel Gafaar, F., Al-Awthan, Y. (2013). 'Protective and curative effect of silymarin against chlorpyrifos-induced immunotoxicity in rats', EKB Journal Management System, 36(2), pp. 106-115. doi: 10.21608/djs.2013.139662
El Elaimy, I., Ibrahim, H., Abdel Gafaar, F., Al-Awthan, Y. Protective and curative effect of silymarin against chlorpyrifos-induced immunotoxicity in rats. EKB Journal Management System, 2013; 36(2): 106-115. doi: 10.21608/djs.2013.139662

Protective and curative effect of silymarin against chlorpyrifos-induced immunotoxicity in rats

Delta Journal of Science
Article 13, Volume 36, Issue 2, June 2013, Page 106-115  XML PDF (1.07 MB)
Document Type: Research and Reference
DOI: 10.21608/djs.2013.139662
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Authors
Ibrahim A. El Elaimy1; Hany M. Ibrahim1; Faten R. Abdel Gafaar1; Yahya S. Al-Awthan2
1Department of Zoology, Faculty of Science, Minufiya University, Shebin El-Kom, Egypt
2Department of Zoology, Faculty of Science, Ibb University, Yemen.
Abstract
Chlorpyrifos (CPF) is a widely used organophosphorus insecticide throughout the world in
agriculture and anti-termites around homes. Silymarin is a naturally occurring substance and has
antioxidant effects. For decades, it has been used clinically in Europe for the treatment of
alcoholic liver disease and as anti-hepatotoxic agent. Therefore, the present study aimed to
assess the protective and curative effect of silymarin in attenuating the CPF-induced
immunotoxicity in rats, by measuring the level of immunoglobulin G (IgG), lymphocyte
viability, neutrophil phagocytic function assay, total white blood cells count (WBC) and relative
differential white blood cells count, as well as nitric oxide (NO) level and catalase activity. The
treatment with CPF decreased lymphocyte viability, neutrophil phagocytic index, total white
blood cells count, relative lymphocyte count, IgG concentration and catalase activity. On the
other hand, a high level of NO was detected upon animal treatment with CPF. Interestingly,
pre- and post-treatment with silymarin to CPF-treated group improved the lymphocyte viability,
total white blood cells count, relative lymphocyte count, catalase activity and the NO level. Preand
post-treatment with silymarin recovered phagocytic activity of neutrophils and restored IgG
level. In conclusion, silymarin has both protective and curative effects against CPF-induced
immunotoxicity may be through its anti-oxidant effects.
Keywords
chlorpyrifos; silymarin; nitric oxide; lymphocyte; phagocytosis; IgG
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