Effect of Some New Aza – Uracil Derivatives in Treatment of Schistosoma mansoni Infection | ||||
Delta Journal of Science | ||||
Article 6, Volume 36, Issue 3, December 2013, Page 161-178 PDF (1.35 MB) | ||||
Document Type: Research and Reference | ||||
DOI: 10.21608/djs.2013.139770 | ||||
View on SCiNiTO | ||||
Authors | ||||
Afrah F. Salama1; Ahmed A. El-Barbary2; Ismail M. Al-Sharkawi3; Yara A. Helal1 | ||||
1Chemistry Department, Biochemistry, Department, Faculty of Science- Tanta University, Egypt. | ||||
2Chemistry Department, Organic Chemistry Section,Department, Faculty of Science- Tanta University, Egypt. | ||||
3Chemistry Department, Biochemistry, Department, Faculty of Science- Tanta University, Egypt | ||||
Abstract | ||||
Praziquantel is now the drug of choice for treatment of schistosomiasis, its use in the control of schistosomiasis at a population level faces some problems, and thus a search for new drugs with antischistosomal activity is urgently needed. In the present study we worked on newly synthesized 1, 2, 4-triazine derivative compounds. The study was carried out on 190 female mice for the assessment of the antischistosomal activity of 1,2,4-triazine compounds, with special reference to histopathological examination and some liver tissues biochemical parameters. The results showed four compounds 3, 6, 7 and 10 caused suppressive effect on the development of granuloma reaction as compared with Schistosoma infected only. Compound 10 had the highest effect in reducing worm burden lesser sever enzymatic dysfunction. Some compounds caused a marked improvement in almost enzymatic activity particularly 5`- nucleotidase, G6P, Na-K ATPase and Mg-ATPase activities. ALT and AST activities decreased than the normal. Also, some compounds showed improvement in catalase and GST enzyme activities indicating their antioxidant effect .Some compounds as 9 and 10 showed antischistosomal activity; also compounds 3, 6 and 10 had anti-inflammatory activity. | ||||
Keywords | ||||
Schistosomiasis; Shistosoma mansoni; Chemotherapy; PZQ; 1; 2; 4-triazine; Oxidative stress | ||||
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