Some Chemical Aspects of 1,2,4-triazine derivatives | ||||
Delta Journal of Science | ||||
Article 8, Volume 37, Issue 1, June 2016, Page 73-85 PDF (1.16 MB) | ||||
Document Type: Research and Reference | ||||
DOI: 10.21608/djs.2016.139921 | ||||
View on SCiNiTO | ||||
Authors | ||||
A. A. El-Barbary⃰; A. M. Sharaf; Bader E-Bader | ||||
Chemistry Department, Faculty of Science, Tanta University, Egypt | ||||
Abstract | ||||
Condensation of 3a,b with some aromatic aldehydes afforded the Schiff bases (4a-f). Reaction of 3a,b with aromatic aldehydes and alkyl phosphites gave the corresponding amino phosphonates (5a-d). Heating 3a,b with 6a-f in POCl3 at 85 °C furnished the amino sulphonamides (7a- l). Acid hydrolysis of compounds 7a,b and 7k) furnished the amines (8a-c). Condensation of 3a, b with 9a,b afforded the cyclized product (10a,b). Reaction of 3a with halo esters afforded 12 and 13. Heating 3a,b with 14a-c afforded 15a-f. Hydrolysis of 15a,b afforded 16a,b. Fusion of 3a,b with 1,4-butane sultone gave sultams (18a,b). The antimicrobial activity o9f some products was tried | ||||
Keywords | ||||
1; 2; 4-triazines; aldehydes; aminophosphonates; sultams; biological activity | ||||
Statistics Article View: 82 PDF Download: 167 |
||||