Bacterial pathogens associated with severity of HCV infection | ||||
Delta Journal of Science | ||||
Article 9, Volume 37, Issue 2, December 2016, Page 207-214 PDF (1.24 MB) | ||||
Document Type: Research and Reference | ||||
DOI: 10.21608/djs.2016.139954 | ||||
View on SCiNiTO | ||||
Authors | ||||
Nanis Gamal Allam1; Mohamed Labib Salem2; Hassan Elbataa3; Maii Moustafa Nabieh1 | ||||
1Microbiology section, Botany Department, Faculty of Science, Tanta University, Tanta, Egypt. | ||||
2Immunology section, Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt. | ||||
3Hepatology, Tropical diseases medicine, Dean of Medicine faculty, Kafr elsheikh University, Egypt. | ||||
Abstract | ||||
Hepatitis C virus (HCV) is a serious pathogen with epidemic ≥ 170 millions and Egypt considered the highest, while immunocompromised chronic HCV patients suffer from serious microbial infections especially bacteria. Aim: investigation of common bacterial infections in patients with chronic HCV in Egypt and its association with HCV severity. Methods: This clinical study was conducted on chronic HCV patients and healthy individuals, while urine and blood samples were collected under optimized conditions. Bacteria were isolated from urine samples and identified using VETIK2 system. Flow cytometry was used for CD56+ and CD3+ levels detection. Alanine/Aspartate aminotransferase (ALT, AST) levels were detected biochemically, enzyme-linked immunosorbent assay (ELISA) was used for diacylglycerol acyltransferase-1 (DGAT1) level detection and HCV PCR was performed for viral load detection. The results: showed that Staphylococcus lentus, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Eschirechia coli were the common bacterial infections. The slight reduction in CD3+and CD56+ levels were coincident with the increase of Alt, AST and DGAT1 levels as patients suffered from high HCV load. Conclusion: HCV patients are immunocompromised and suffer from serious secondary bacterial infections which increased the severity of HCV infection. | ||||
Keywords | ||||
Hepatitis C HCV; Lactobacillus acidophilus and Bifidobacterium bifidum; CD3+; CD56+; IFN-α and ribavirin | ||||
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