Clinical and Histopathological study of calcineurin inhibitors induced gingival hyperplasia after kidney transplant.
El-Kateb, H., Khashaba, O., Bazeed, F., Donia, A., El-Nablaway, M., EL-Zehary, R. (2021). Clinical and Histopathological study of calcineurin inhibitors induced gingival hyperplasia after kidney transplant.. EKB Journal Management System, 67(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 407-418. doi: 10.21608/edj.2021.50020.1341
Hend H El-Kateb; Omar Khashaba; Fagr Bazeed; Ahmed Donia; Mohammad El-Nablaway; Rehab rizk EL-Zehary. "Clinical and Histopathological study of calcineurin inhibitors induced gingival hyperplasia after kidney transplant.". EKB Journal Management System, 67, Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2021, 407-418. doi: 10.21608/edj.2021.50020.1341
El-Kateb, H., Khashaba, O., Bazeed, F., Donia, A., El-Nablaway, M., EL-Zehary, R. (2021). 'Clinical and Histopathological study of calcineurin inhibitors induced gingival hyperplasia after kidney transplant.', EKB Journal Management System, 67(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 407-418. doi: 10.21608/edj.2021.50020.1341
El-Kateb, H., Khashaba, O., Bazeed, F., Donia, A., El-Nablaway, M., EL-Zehary, R. Clinical and Histopathological study of calcineurin inhibitors induced gingival hyperplasia after kidney transplant.. EKB Journal Management System, 2021; 67(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 407-418. doi: 10.21608/edj.2021.50020.1341

Clinical and Histopathological study of calcineurin inhibitors induced gingival hyperplasia after kidney transplant.

Egyptian Dental Journal
Article 11, Volume 67, Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology) - Serial Number 3, January 2021, Page 407-418  XML PDF (2.52 MB)
Document Type: Original Article
DOI: 10.21608/edj.2021.50020.1341
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Authors
Hend H El-Kateb1; Omar Khashaba2; Fagr Bazeed3; Ahmed Donia4; Mohammad El-Nablaway5; Rehab rizk EL-Zehary email orcid 6
1BDS, Faculty of Dentistry, Mansoura University, Egypt.
2Professor of Oral Medicine & Periodontology, Faculty of Dentistry, Mansoura University, Egypt.
3Professor of Biochemistry,Faculty of Medicine, Mansoura University, Egypt.
4Consultant of Nephrology, Mansoura Urology and Nephrology Center Mansoura University, Egypt.
5Lecturer of Medical Biochemistry, Faculty of Medicine, Mansoura University, Egypt.
6Assistant Professor of Oral Biology, Faculty of Dentistry, Mansoura University, Egypt.
Abstract
Objective: Perform clinical and histopathological evaluations of gingival hyperplasia after kidney transplantation in patients receiving either cyclosporine (CsA) or tacrolimus (TAC). Subjects and Methods: A sample of 54 male renal transplant patients who have undergone immunosuppressive regimen (CsA=28 and TAC=26) were examined in respect to demographic, pharmacologic, and periodontal variables. Gingival overgrowth (GO) was assessed by using gingival enlargement index. In addition gingival biopsies were examined histopathologically with Hematoxylin and eosin (H&E) stain and Immunohistochemistry using caspase 3 expression and histomorphometric Analyses. Furthermore the serum level of matrix metalloproteinase (MMP2) was assessed in the two groups. Data were analyzed statistically using the Statistical Package for Social Sciences (SPSS). Results: Considering gingival enlargement, there was a statistically significant difference between (CsA) and (TAC) group’s index with higher mean in (CsA) group versus (TAC) group. Considering the gingival bleeding index, there was a statistically significant difference between (CsA) and (TAC) groups with higher mean in (CsA) group versus (TAC) group and regarding serum (MMP2) level, there was statistically significant difference between (CsA) and (TAC) groups with lower mean in (CsA) group versus (TAC) group. Histopathologically, the degree of tacrolimus-influenced gingival enlargement was lesser in comparison to (CsA) group. Conclusions: (CsA) has a greater degree of gingival enlargement than (TAC) as shown clinically and histolopathologically but the serum level of (MMP2) was higher in (TAC) group than in the (CsA) group. (MMP2) may have a role in the mechanism of gingival enlargement.
Keywords
Immunosuppressants; Cyclosporine; Tacrolimus; Drug-induced gingival overgrowth; MMP2
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