THERAPEUTIC EFFECT OF TWO FLUORIDE VARNISHES INTENSIVE MODE ON WHITE SPOT LESIONS (RANDOMIZED CLINICAL TRIAL) | ||||
Alexandria Dental Journal | ||||
Article 3, Volume 46, Issue 2, August 2021, Page 166-171 PDF (935.98 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/adjalexu.2020.28735.1063 | ||||
View on SCiNiTO | ||||
Authors | ||||
Ahmed Ibrahim Mekki 1; Karin Dowidar 2; Dalia Talaat3 | ||||
1Pediatric dentistry,faculty of dentistry ,Alexandria university | ||||
2Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University | ||||
3pediatric dentistry,faculty of dentistry,Alexandria university | ||||
Abstract | ||||
Background: Fluoride varnish has been used as therapeutic agent for white spot lesions. Bio-active calcium and phosphate was included in the varnish in order to provide better subsurface remineralization. One of the most promising modifications is the addition of casein phosphopeptide amorphous calcium phosphate to fluoride varnish (MI varnish). Objectives: Evaluate the therapeutic effect of intensive application of casein phosphopeptide amorphous calcium phosphate fluoride (CCP-ACPF) varnish and fluoride varnish on the activity of enamel white spot lesions (WSLs) in primary teeth over a 6 weeks follow-up period. Materials and Methods: Forty-four participants with at least 4 active WSLs each were divided randomly into two groups. Test group (22 participants) received three times intensive professional application of MI varnish with two weeks apart. Control group (22 participants) received three times intensive professional application of Duraphat with two weeks apart. Lesions’ activity in both groups was assessed using DIAGNOdent and visio-tactile lesion activity index at baseline and at 6 weeks. Results: Both groups had a significant decrease in mean DIAGNOdent scores and number of active WSLS when compared to their baseline mean score. However when comparing the results of both groups, the control group (Duraphat varnish) had a significant decrease in DIAGNOdent mean score and number of active WSLs when compared to the test group (MI varnish). Conclusions: Intensive application of fluoride varnish decreases caries lesion activity which may lead to the arrest of the early caries lesions. Duraphat varnish is superior to MI varnish in remineralization of early caries lesions. | ||||
Keywords | ||||
WSLs; remineralization; MI varnish; Duraphat; CPP-ACP | ||||
References | ||||
Cochrane NJ, Cai F, Huq NL, Burrow MF, Reynolds EC. New Approaches to enhanced remineralization of tooth enamel. J Dent Res. 2010; 1187-97.
American Academy of Pediatric Dentistry.Guideline on fluoride therapy.Ped Dent. 2014;E176-8.
Weinstein P, Spiekerman C, Milgrom P. Randomized equivalence trial of intensive and semiannual applications
of fluoride varnish in the primary dentition. Caries research. 2009;484-90.
RehderNeto FC, Maeda FA, Turssi CP, Serra MC. Potential agents to control enamel caries-like lesions. J Dent
2009; 786-90.
Wefel JS, Harless JD. The use of saturated DCPD in remineralization of artificial caries lesions in vitro. J Den Res. 1987 ;1640-3.Iijima Y, Takagi O, Ruben J, Arends J. In vitro remineralization of in vivo and in vitro formed enamel lesions.Caries research. 1999:206-13.
Aimutis WR. Bioactive properties of milk proteins focus on anticariogenesis. J Nutr. 2004:989-95.
Llena C, Leyda AM, Forner L. CPP-ACP and CPP-ACFP versus fluoride varnish in remineralisation of early
caries lesions. A prospective study.Eur J Paediatr Dent. 2015:181-6.
Thakkar PJ, Badakar CM, Hugar SM, Hallikerimath S, Patel PM, Shah P. An in vitro comparison of casein
phosphopeptide-amorphous calcium phosphate paste, casein phosphopeptide-amorphous calcium phosphate paste with fluoride and casein phosphopeptide-amorphous calcium phosphate varnish on the inhibition of demineralization and promotion of remineralization of enamel.Journal of Indian Society of Pedodontics and Preventive Dentistry. 2017 Oct 1:312.
Salman nr, el-tekeya mm, bakry ns, soliman s. remineralization effect of fluoride varnish containing casein phosphopeptide amorphous calcium phosphate on caries-like lesions in primary teeth (in vitro study). alexandriadental journal. 2019 apr 1;13-6.
Nyvad B, Baelum V. Nyvad criteria for caries lesion activity and severity assessment: a validated approach for clinical management and research. Caries research. 2018:397-405.
Dikmen B. Icdas II criteria (international caries detection and assessment system).Journal of Istanbul University Faculty of Dentistry.2015:63.
Wright JT, Hanson N, Ristic H, Whall CW, Estrich CG, Zentz RR. Fluoride toothpaste efficacy and safety in children younger than 6 years: a systematic review. The Journal of the American Dental Association.2014 Feb 1:182-9.
Colgate.DuraphatVarnish.https://www.colgateprofessional.com.au/products/products-list/colgate-durapath- varnish-single-dose (accessed 20/1/2020).
GC .MI varnish.https://www.gceurope.com/products/mivarnish/ (accessed 20/1/2020).
Pinelli C, Serra MC, Loffredo LD. Validity and reproducibility of a laser fluorescence system for detecting the
activity of white-spot lesions on free smooth surfaces in vivo. Caries research. 2002;19-24.
Autio-Gold JT, Courts F. Assessing the effect of fluoride varnish on early enamel carious lesions in the primary dentition. J Am Dent Assoc 2001:1247–1253.
American Academy of Pediatric Dentistry.Guideline on Fluoride Therapy, 2018 http://www. aapd.org/media/Policies_Guidelines. P_FluorideUse.pdf.
Tuloglu N, Bayrak S, Tunc ES, Ozer F. Effect of fluoride varnish with added casein phosphopeptide-amorphous calcium phosphate on the acid resistance of the primary enamel. BMC oral health. 2016 Dec;103.
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