Role of HER2 and Claudins in Subtypes of Urothelial Carcinoma Identified Bygata3 and Cytokeratin56 Immunohistochemical Study
Saad, E., Ibrahim, K., Emaraa, N., El-Sebaaie, A., omar, E., youssef, S. (2021). Role of HER2 and Claudins in Subtypes of Urothelial Carcinoma Identified Bygata3 and Cytokeratin5\6 Immunohistochemical Study. EKB Journal Management System, 38(Academic issue), 128-146. doi: 10.21608/bmfj.2021.140350
Eman Saad; Kareem Ibrahim; Nashwa Emaraa; Amr El-Sebaaie; Eman omar; Samia youssef. "Role of HER2 and Claudins in Subtypes of Urothelial Carcinoma Identified Bygata3 and Cytokeratin5\6 Immunohistochemical Study". EKB Journal Management System, 38, Academic issue, 2021, 128-146. doi: 10.21608/bmfj.2021.140350
Saad, E., Ibrahim, K., Emaraa, N., El-Sebaaie, A., omar, E., youssef, S. (2021). 'Role of HER2 and Claudins in Subtypes of Urothelial Carcinoma Identified Bygata3 and Cytokeratin5\6 Immunohistochemical Study', EKB Journal Management System, 38(Academic issue), pp. 128-146. doi: 10.21608/bmfj.2021.140350
Saad, E., Ibrahim, K., Emaraa, N., El-Sebaaie, A., omar, E., youssef, S. Role of HER2 and Claudins in Subtypes of Urothelial Carcinoma Identified Bygata3 and Cytokeratin5\6 Immunohistochemical Study. EKB Journal Management System, 2021; 38(Academic issue): 128-146. doi: 10.21608/bmfj.2021.140350

Role of HER2 and Claudins in Subtypes of Urothelial Carcinoma Identified Bygata3 and Cytokeratin5\6 Immunohistochemical Study

Benha Medical Journal
Article 9, Volume 38, Academic issue, February 2021, Page 128-146  XML PDF (1.33 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2021.140350
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Authors
Eman Saad1; Kareem Ibrahim2; Nashwa Emaraa1; Amr El-Sebaaie3; Eman omar1; Samia youssef4
1Department of Pathology, Benha faculty of medicine, Benha University, Egypt.
2Department of urology, Benha faculty of medicine, Benha University, Egypt.
3Department of Pathology, Military Medical Academy, Cairo, Egypt
4Department of Pathology, Benha faculty of medicine, Benha University, Egypt
Abstract
Background: Bladder cancer is globally the ninth, most common malignancy, and the thirteenth most common cause, of cancer death, associated with high morbidity and mortality, if not treated optimally. Bladder cancers can be divided into molecular subtypes, referred to luminal and basal with distinct clinical behaviors. HER2 is one of the established therapeutic targets in many cancers. Claudins are tight junction proteins, known to modulate therapy resistance in cancer cells. Aim: This study aimed to assess Claudins and HER2 status in the context of tumor molecular subtypes, identified by GATA3 and CK5/6 expression, that may help to select urothelialcarcinoma patients, most likely to respond to immunotherapy. Materials and Methods: This retrospective study was done upon 50 cases of conventional urothelialcarcinoma. GATA3, CK5/6, HER2, Claudins1&4 and P53immunostaining were done and correlated with clinico-immuno-pathological parameters. Results: Bladder cancers could be assigned to main intrinsic molecular subtypes, referred to luminal, basal and double negative. Basal & double negative bladder cancers were more aggressive, when compared to luminal cancers. Positive significant statistical correlation was found between HER2, claudin1 and P53 and clinic-immuno-pathologicalparametersas tumor size, grade, TNM stage, LVI, tumor budding and aggressive molecular subtypes (P-value< 0.05). Negative significant statistical correlation was found between claudin4 and fore mentioned clinico-immuno-pathologicalparameters (P-value< 0.05). Conclusions: The molecular subtypes of bladder cancers, HER2, claudin1&4 and P53 can be used for prognostic and therapeutic stratification of bladder cancers patients, and may affect patient outcome.
Keywords
Molecular subtypes; HER2; Claudins1&4
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