Myocardial Protection with Glucose-Insulin-Potassium Infusion during Cardiopulmonary Bypass for Coronary Revascularization | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 6, Volume 82, Issue 2, January 2021, Page 212-216 PDF (411.59 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhm.2021.140446 | ||||
View on SCiNiTO | ||||
Authors | ||||
Essam Ezzat Abd El-Hakeem1; Ahmed Elsaied Abd Elrahman Aly2; Osama Salah El Din Mahmoud 2; Ahmad Hamody Hassan2 | ||||
1Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Assiut University | ||||
2Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Sohag University, Egypt | ||||
Abstract | ||||
Background: Sodi-Pallares and colleagues first time introduced use of glucose-insulin and potassium (GIK) solution for myocardial protection. They used this solution in patients with acute myocardial infarction and concluded that GIK solution limited electrocardiographic changes in these patients. Objective: To investigate the effectiveness of the GIK solution regarding myocardial protection evaluated by postoperative creatine kinase MB (CKMB) and cardiac troponin I levels. Method: In this prospective, randomized clinical trial, sixty-four patients were assigned into two groups: GIK group, in which glucose-insulin and potassium infusion were given during surgery, and non-GIK group in which only saline infusion was given during the procedure. Results: All CK-MB values were lower in the GIK group than the Non-GIK group in the postoperative period (6, 12 and 24 hours’ samples) with statistically significant results. Troponin values were lower in the GIK group versus the Non-GIK group after 6 and 12 hours with statistical significance (P < 0.001 and 0.022 respectively). Conclusion: The addition of GIK infusion throughout the operation to standard myocardial protective techniques in patients undergoing on-pump coronary artery bypass graft (CABG) surgery attenuates myocardial ischemic injury. | ||||
Keywords | ||||
CABG; Cardiac Protection; Inotropic support; GIK | ||||
Statistics Article View: 255 PDF Download: 429 |
||||