Interaction of Coenzyme Q10 with Dipalmitoylphosphatidylcholine Liposomes
Shafaa, M., Kareem, H., Elshazly, A., Dakrory, A., Elsyed, M. (2017). Interaction of Coenzyme Q10 with Dipalmitoylphosphatidylcholine Liposomes. EKB Journal Management System, 34(part1), 245-257. doi: 10.21608/jsrs.2018.14047
Medhat W. Shafaa; Hossam S. Kareem; Amany H. Elshazly; Amira Z. Dakrory; Maha R. Elsyed. "Interaction of Coenzyme Q10 with Dipalmitoylphosphatidylcholine Liposomes". EKB Journal Management System, 34, part1, 2017, 245-257. doi: 10.21608/jsrs.2018.14047
Shafaa, M., Kareem, H., Elshazly, A., Dakrory, A., Elsyed, M. (2017). 'Interaction of Coenzyme Q10 with Dipalmitoylphosphatidylcholine Liposomes', EKB Journal Management System, 34(part1), pp. 245-257. doi: 10.21608/jsrs.2018.14047
Shafaa, M., Kareem, H., Elshazly, A., Dakrory, A., Elsyed, M. Interaction of Coenzyme Q10 with Dipalmitoylphosphatidylcholine Liposomes. EKB Journal Management System, 2017; 34(part1): 245-257. doi: 10.21608/jsrs.2018.14047

Interaction of Coenzyme Q10 with Dipalmitoylphosphatidylcholine Liposomes

Journal of Scientific Research in Science
Article 16, Volume 34, part1, September 2017, Page 245-257  XML PDF (676.35 K)
Document Type: Original Article
DOI: 10.21608/jsrs.2018.14047
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Authors
Medhat W. Shafaa1; Hossam S. Kareem2; Amany H. Elshazly3; Amira Z. Dakrory4; Maha R. Elsyed email 5
1Physics department, Faculty of Science, Helwan University, Cairo, Egypt,
2Physiological optics department, Research Institute of Ophthalmology, Giza,
3Departments of Biochemistry and Pharmacology, Research Institute of Ophthalmology, Giza
4Physics department, Faculty of women for arts, science and education Ain Shams University,Egypt.
5Physics department, Faculty of women for arts, science and education Ain Shams University,Egypt
Abstract
The goal of this study to investigate the influence of antioxidant as coenzyme Q10 on structural changes of model lipid membranes as DPPC by  using Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The results obtained indicate that the greater effect of CoQ10 upon the incorporation into negatively charged liposomes in comparison with the other liposome formulations. The incorporated CoQ10 is probably associated with the lipid bilayers, interacted to a large extent with them, and perturbed them which results in the strong broadening and shift to lower temperature 94 °C of the major characteristic endothermic peak of pure DPPC that exists at 105 °C. The FT-IR spectra of samples showed that Incorporation of CoQ10 into neutrally, positively and negatively charged DPPC liposomes showed significant change in the frequency of the antisymmetric CH2 stretching bands in the acyl chain implying that CoQ10 create a conformational disorder within the acyl chains of phospholipids.  In other words, it had significant effect on the order of the membrane.
 
 
Keywords
Liposomes – Coenzyme Q10 – DSC – Encapsulation – FTIR
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