THE EFFECT OF SYSTEMIC ADMINISTRATION OF CO-ENZYME Q10 ON ORTHODONTIC RELAPSE IN A RABBIT MODEL | ||||
| Alexandria Dental Journal | ||||
| Article 8, Volume 46, Issue 2, August 2021, Page 197-204 PDF (1.17 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjalexu.2020.35051.1079 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ahmed M. Madian  1; Essam M. Abdallah2; Nadia M. El Harouni3; Shadia H. Abdelmajeed4
| ||||
| 1Assistant lecturer, Department of Orthodontic, Alexandria University | ||||
| 2Professor of Orthodontic, Faculty of Dentistry, Alexandria university | ||||
| 3Department of Orthodontics, Faculty of Dentistry, Alexandria University, Egypt | ||||
| 4Professor of Oral Biology, Faculty of Dentistry, Alexandria University | ||||
| Abstract | ||||
| ABSTRACT Introduction: Several pharmacological agents have been investigated for their ability to reduce orthodontic relapse. Objective: The current research was performed to test the short term influence of systemic Co-enzyme Q10 administration on post-orthodontic relapse in rabbits. Materials and methods : Thirty New Zealand rabbits were randomly divided into 2 groups (n=15) : Experimental receiving Co-enzyme Q10 and control receiving control vehicle. Orthodontic tooth movement was performed using NiTi coil spring for 21 days for both groups, then this coil spring was detached, and teeth were allowed to relapse for another 21 days. Amounts and percentages of relapse were assessed on three-dimensional models of the experimental and control groups at two time points (T2: 1 week of relapse) and (T3: three weeks of relapse). Animals were sacrificed after 3 weeks of relapse for histological examination using H&E stain. Also, histomorphometric analysis was performed. Statistical analysis was computed. Significance was judged at the 5% level. Results: The amount and percentage of relapse showed insignificant difference among experimental and control groups, although relapse in the experimental group was less. However, the histological analysis showed that Co-enzyme Q10 resulted in significant reduction in osteoclast count with the area of new bone formation being significantly increased. Signs of bone resorption were more evident in the control group. Conclusions: From the present results, it could be concluded that Co-enzyme Q10 is capable of altering bone resorption pattern favorably in spite of its short term ineffectiveness in minimizing relapse. | ||||
| Keywords | ||||
| Co-enzyme Q10; tooth movement; relapse; osteoclast | ||||
| References | ||||
|
Oppenheim A. The crisis in orthodontia. Part I. Tissue changes during retention. Int J Orthod 1934;6:639–44.
Yoshida Y, Sasaki T, Yokoya K, Hiraide T, Shibasaki Y. Cellular roles in relapse processes of experimentally-moved
rat molars. J Electron Microsc (Tokyo) 1999;48:147-57.
Littlewood SJ, Russell JS, Spencer RS. Why do orthodontic Cases relapse? Orthodontic Update 2009;2:43–9.
Hassan AH, Al-Hubail A, Al-Fraidi AA. Bone inductive proteins to enhance post orthodontic stability. Angle
Orthod 2010;80:1051-60.
Adachi H, Igarashi K, Mitani H, Shinoda H. Effects of topical administration of a bisphosphonate (risedronate)
on orthodontic tooth movements in rats. J Dent Res. 1994;73:1478-86.
Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, Vega AF, Mata M, Pavón AD, et al. Coenzyme Q10 therapy.
Mol Syndromol. 2014;5:187-97.
Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys
Acta. 1995;1271:195-204.
Garrido-Maraver J., Cordero MD., Oropesa-Avila M., Vega AF., de la Mata M., Pavon AD., et al. Clinical
applications of coenzyme Q10. Front Biosci. 2014;19:619-33.
Thorne Research, Inc. CoenzymeQ10. Monograph. Altern Med Rev. 2007;12:159-68.
YonedaT.,TomofujiT.,EkuniD.,AzumaT.,EndoY.,KasuyamaK.,etal.Anti-agingeffectsofco-enzymeQ10on
periodontal tissues. Dent Res. 2013;92:735-9.
Varela-Lopez A., Bullon P., Battino M., Ramirez-Tortosa M., Ochoa J.,Cordero M.,et al. Coenzyme Q Protects
Against Age-Related Alveolar Bone Loss Associated to n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating
Mitochondrial Mechanisms. J Gerontol A Biol Sci Med Sci. 2016;71:593-600.
Moon HJ., Ko WK., Jung MS., Kim JH., Lee WJ., Park KS., et al. Coenzyme Q10 Regulates Osteoclast and
Osteoblast Differentiation. Journal of Food Science, 2013;78: H785–H791.
KilkennyC,BrowneWJ,CuthillIC,EmersonM,AltmanDG.Improvingbioscienceresearchreporting:theARRIVE
guidelines for reporting animal research. PLoS Biol 2010;8:e1000412.
Venkataramana V, Chidambaram S, Reddy BV, Goud ESS, Arafath M, Krishnan S. Impact of Bisphosphonate on
Orthodontic tooth movement and osteoclastic count: An Animal Study. Journal of international oral health.
2014;6:1-8.
CharanJ,BiswasT.Howtocalculatesamplesizefordifferentstudydesignsinmedicalresearch?IndianJPsychol
Med. 2013;35:121-6.
FaulF.,ErdfelderE.,LangAG.,BuchnerA.G*Power3:Aflexiblestatisticalpoweranalysisprogramforthesocial,
behavioral, and biomedical sciences. Behavior Research Methods.2007;39:175-91.
BullonP.,QuilesJL.,MorilloJM.,RubiniC.,GoteriG.,Granados-PrincipalS.,etal.Gingivalvasculardamagein atherosclerotic rabbits: Hydroxytyrosol and squalene benefits. Food and Chemical Toxicology. 2009;47:2327–
31.
Ramirez-TortosaM.,GranadosS.,Ramirez-TortosaC.,OchoaJ.,CamachoP.,Garćıa-ValdésL.,etal.Oxidative
stress status in liver mitochondria and lymphocyte DNA damage of atherosclerotic rabbits supplemented with
water soluble coenzyme Q10. BioFactors. 2008;32:263–73.
Vieira GM., Chaves SB., Ferreira VM., Freitas KM., Amorim RF. The effect of simvastatin on relapse of tooth
movement and bone mineral density in rats measured by a new method using micro-tomography. Acta Cir Bras
2015;30:319-27.
AlSwafeeri H., ElKenany W., Mowafy M., Karam S. Effect of local administration of simvastatin on post-
orthodontic relapse in a rabbit model. Am J Orthod Dentofacial Orthop. 2018;153:861-71.
Drury R.A., Wallington E.A. Carleton’s Histological technique. 5th Edition, Oxford university press, New York.
1980.
Takano-yamamoto T., Kawakami M., Kobayashi Y., Yamashiro T., Sakuda M. The effect of local application of
1,25-dihydroxycholecalciferol on osteoclast numbers in orthodontically treated rats. J Dent Res 1992;71(1);53-
9.
Caglaroglu M., Erdem A. Histopathologic investigation of the effects of prostaglandin E2 administered by
different methods on tooth movement and bone metabolism. Korean J Orthod. 2012; 42(3): 118-28.
Garrett IR. Assessing bone formation using mouse calvarial organ cultures. Methods Mol Med 2003; 80:183-
98.
Igarashi K, Mitani H, Adachi H, Shinoda H. Anchorage and retentive effects of a Bisphosphonate (AHBuBP) on
tooth movements in rats. Am J Orthod Dentofacial Orthop 1994 ; 106 (3) : 279-89.
Mapara M., Thomas BS., Bhat KM. Rabbit as an animal model for experimental research. Dent Res J. 2012;9:111-8.
HidakaT.,FujiiK.,FunahashiI.,FukutomiN.,HosoeK.SafetyassessmentofcoenzymeQ10(CoQ10).Biofactors. 2008;32:199-208.
Zhang XX., Qian KJ., Zhang Y., Wang ZJ., Yu YB., Liu XJ., et al. Efficacy of coenzyme Q10 in mitigating spinal cord injury-induced osteoporosis. Mol Med Rep. 2015;12:3909-15.
Zheng D., Cui C., Yu M., Li X., Wang L., Chen X., et al.Coenzyme Q10 promotes osteoblast proliferation and differentiation and protects against ovariectomy-induced osteoporosis. Mol Med Rep. 2018;17:400-7.
Kilic N., Oktay H., Ersoz M. Effects of force magnitude on tooth movement : an experimental study in rabbits. Eur J Orthod. 2010;32:154-8.
Roche JJ., Cisneros GJ., ACS G. The effect of acetaminophen on tooth movement in rabbits. Angle Orthod. 1997;67:231-6.
Hosoe K, Kitano M, Kishida H, Kubo H., Fujii K, Kitahara M. Study on safety and bioavailability of ubiquinol (Kaneka QHTM) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007;47:19-28.
Bank G., Kagan D., Madhavi D. Coenzyme Q10: Clinical Update and Bioavailability. Journal of Evidence-Based Complementary & Alternative Medicine. 2011;16:129–37.
Bhagavan HN., Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007;7(suppl):S78-S88.
Miles MV., Horn P., Miles L., Tang P., Steele P., DeGraw, T. Bio-equivalence of coenzyme Q10 from over the counter supplements. Nutr Res. 2002:22:919-29.
ZaghloulA.,GurleyB.,KhanM.,BhagavanH.,ChopraR.,ReddyI.Bioavailabilityassessmentoforalcoenzyme Q10 formulations in dogs. Drug develop Ind Pharm. 2002;28:1195 -200.
Gad A., Abdallah E., El-Harouni N., Omar S. Evaluation of the effect of systemic omega-3 polyunsaturated fatty acids on post-orthodontic relapse in a rabbit model. [Phd Thesis]. Egypt: Alexandria; 2018.
Abdel Hafez S., Ismail H., El Harouni N., Ali H., Yehia M. Effect of periodontally injected platelet rich plasma on relapse and alveolar bone remodelling after orthodontic tooth movement in rabbits [Phd Thesis]. Egypt: Alexandria; 2017.
AlhasyimiAA.,PudyaniPP.,AsmaraW.,AnaID.Enhancementofpost-orthodontictoothstabilitybycarbonated hydroxyapatite-incorporated advanced platelet-rich fibrin in rabbits. Orthod Craniofac Res. 2018 May;21(2):112-118.
Van Leeuwen EJ., Maltha JC., Kuijpers-Jagtman AM., van 't Hof MA. The effect of retention on orthodontic relapse after the use of small continuous or discontinuous forces. An experimental study in beagle dogs. Eur J Oral Sci. 2003;111:111-6.
| ||||
|
Statistics Article View: 416 PDF Download: 599 |
||||
