Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker | ||||
| International Journal of Medical Arts | ||||
| Article 3, Volume 3, Issue 2, April 2021, Page 1181-1187 PDF (1.21 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2021.47667.1197 | ||||
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| Authors | ||||
Mohamed Hussein Abdelazim  1; Ahmed Abd-alrahman Ibrahim1; Amr Mohammed El-hakeem2
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| 1Department of Otorhinolaryngology, Dameitta Faculty of Medicine, Al-Azhar University, Egypt | ||||
| 2Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt | ||||
| Abstract | ||||
Background: The relationship between gastroesophageal reflux [GER] and chronic rhinosinusitis [CRS] has been discussed in several studies, but a direct relationship could not be established. However, both conditions are highly prevalent. Aim of the work: The study aimed to evaluate the nasal and salivary pepsin as a biomarker for GER in CRS patients. Patients and Methods: Fifty patients with CRS were included; 28 males and 22 females, and 50 healthy volunteers; 25 males and 25 females served as controls. Peptest was performed for all subjects. Results: Pepsin positivity was found to have a slight increase in CRS salivary samples than the control group. However, the difference was insignificant [P >0.05], in contrast with nasal samples, which was estimated to have a statistically significant difference [P <0.05] in the second and third samples. As regard pepsin concentration in salivary samples, it was found to show a statistically significant difference [P <0.01] in all samples, while it was non-significant in all nasal samples [P>0.05]. Conclusion: CRS patients have a higher positive rate of pepsin in salivary and nasal secretions; however, no significant more pepsin in saliva or nasal secretions is regarded as CRS-patients than healthy controls. | ||||
| Keywords | ||||
| Chronic Rhinosinusitis; Salivary; Nasal; Pepsin; Gastroesophageal Reflux Disease | ||||
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