Pulmonary functions and exercise tolerance before and after device closure of atrial septal defect: Determinants and Outcome. | ||||
| Zagazig University Medical Journal | ||||
| Article 21, Volume 29, Issue 2.1, March and April 2023, Page 133-141 PDF (387.17 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2021.55148.2061 | ||||
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| Authors | ||||
Ragab Mahfouz1; Marwa Mohammed Gad2; Mohammad Gouda Mohammad3; Ali Galal Behairy  4
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| 1Professor, Cardiology department, Faculty of Medicine-Zagazig University, Egypt, | ||||
| 2Professor, Cardiology department, Faculty of Medicine-Zagazig University, Egypt | ||||
| 3Cardiology department, Faculty of medicine, Zagazig university, Zagazig, Egypt | ||||
| 4Cardiology.medicine.zagazig.benha.Egypt | ||||
| Abstract | ||||
| Background: Secundum atrial septal defects (ASDs) are the most common congenital heart diseases and its closure affords changes in the function of the pulmonary activities. The Aim of this work: to demonstrate that the closure ASD not only improves cardiac function but also results in symptomatic relief by improving functional class by improving exercise tolerance and pulmonary functions. Methods: This is a prospective study was conducted on 100 patients underwent device closure of secundum ASD. Investigations included NT-pro-brain natriuretic peptide levels (NT-pro-BNP), electrocardiography, chest X-ray, transthoracic echocardiogram, spirometry, and 6-min walk test, before and 3 months after the procedure. Results: All patients were classified according to significant symptomatic improvement into group I (not improved) and group II (improved). Regards NYHA classification, pulmonary hypertension, tricuspid regurgitation and NT-pro-BNP, there was statistically significant lower values both pre-closure and post-closure in the improved group (p < 0.001). There was statistical significant difference in pulmonary functions (spirometry and 6-minute walk test) in ASD patients before and 3 months after ASD closure in both groups as all parameters (FEF 25-75, FVC, and FEV1 and 6-minute walk test) as they were statistically significant higher values in the improved group both pre-closure and post-closure. The significant predictors was age < 48, ASD size ≤35, pulmonary hypertension (mild/moderate), FEF 75-25 ≥61, FVC≥67, FEV 1%≥64 and 6-MWTD ≥325 Conclusion: Transcatheter ASD device closure leads to significant improvement in the heart dimensions especially right-sided dimensions and functional class by improving exercise tolerance and pulmonary functions. | ||||
| Keywords | ||||
| ASD; NYHA; 6-minute walk test; spirometry | ||||
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