Interleukin-9: Investigating its possible role in liver cirrhosis progression and in tumour promotion of hepatocellular carcinoma in chronic HCV infected patients, A single centre study
Abdelhamid, A., Abdel Salam, S., Faheem, H., Ahmed, O., Salah, M., Aly, H. (2021). Interleukin-9: Investigating its possible role in liver cirrhosis progression and in tumour promotion of hepatocellular carcinoma in chronic HCV infected patients, A single centre study. EKB Journal Management System, 2(2), 260-270. doi: 10.21608/mid.2021.56732.1107
Amira Esmail Abdelhamid; Shimaa Ahmed Abdel Salam; Heba Ahmed Faheem; Ossama Ashraf Ahmed; Manar Mohamed Salah; Heba Ismail Aly. "Interleukin-9: Investigating its possible role in liver cirrhosis progression and in tumour promotion of hepatocellular carcinoma in chronic HCV infected patients, A single centre study". EKB Journal Management System, 2, 2, 2021, 260-270. doi: 10.21608/mid.2021.56732.1107
Abdelhamid, A., Abdel Salam, S., Faheem, H., Ahmed, O., Salah, M., Aly, H. (2021). 'Interleukin-9: Investigating its possible role in liver cirrhosis progression and in tumour promotion of hepatocellular carcinoma in chronic HCV infected patients, A single centre study', EKB Journal Management System, 2(2), pp. 260-270. doi: 10.21608/mid.2021.56732.1107
Abdelhamid, A., Abdel Salam, S., Faheem, H., Ahmed, O., Salah, M., Aly, H. Interleukin-9: Investigating its possible role in liver cirrhosis progression and in tumour promotion of hepatocellular carcinoma in chronic HCV infected patients, A single centre study. EKB Journal Management System, 2021; 2(2): 260-270. doi: 10.21608/mid.2021.56732.1107

Interleukin-9: Investigating its possible role in liver cirrhosis progression and in tumour promotion of hepatocellular carcinoma in chronic HCV infected patients, A single centre study

Microbes and Infectious Diseases
Article 11, Volume 2, Issue 2, May 2021, Page 260-270  XML PDF (342.5 K)
Document Type: Original Article
DOI: 10.21608/mid.2021.56732.1107
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Authors
Amira Esmail Abdelhamid email 1; Shimaa Ahmed Abdel Salamorcid 1; Heba Ahmed Faheem2; Ossama Ashraf Ahmed3; Manar Mohamed Salah4; Heba Ismail Aly4
1medical microbiology and immunology department, faculty of medicine, Ain Shams university, Cairo, Egypt
2Internal Medicine Department, Gastroenterology and Hepatology unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3Internal Medicine Department, Gastroenterology and Hepatology unit, Faculty of Medicine, Ain Shams University
4Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: Cytokines play an essential role in the pathogenesis of hepatitis C virus (HCV) related cirrhosis and hepatocellular carcinoma (HCC). Interleukin-9 (IL-9) participates in inflammation, autoimmunity and tumor immunity. IL-9 was reported to affect liver fibrosis, severity and prognosis of HCV related diseases.
Aim of the study: To assess the potential correlation of serum IL-9 level and its receptor with the progression and prognosis of patients having HCV related chronic liver disease and its probable association with hepatocellular carcinoma.
Methods: Sixty-eight patients having HCV chronic liver disease and 20 apparently healthy controls (HCs) were enrolled in the study. The patients were grouped into 3 groups: 18 patients having compensated chronic liver disease (CCLD), 18 patients having decompensated chronic liver disease, and 32 patients having hepatocellular carcinoma (HCC). Serum IL-9 level was estimated by ELISA and IL-9 receptor (IL-9R) gene expression was assessed by RT-PCR in HCC group and HCs.
Results: IL-9 level was significantly higher in patients in comparison to HCs and there was statistically significant difference between the 3 patients’ groups (p < 0.001). IL-9 was correlated with different laboratory and clinical parameters. At a cut-off value of >1600pg/ml, IL-9 had the ability to differentiate between CCLD group and HCC group with 75% sensitivity and 94.44% specificity. There was a highly significant statistical difference between HCC group and HCs in IL-9R gene expression (p < 0.001).
Conclusion: Serum IL-9 level is higher in chronic HCV infected patients than in HCs. IL-9R gene expression is higher among HCC patients than in HCs.
Keywords
Interleukin-9; Interleukin-9 receptor; HCV; hepatocellular carcinoma
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