Anti-Diabetic Effect of Balanites Aegyptiacea Leaves Extract (Heglig) by Regulation of Erythrocyte Glucose Uptake in Diabetic Patients Type 2 in Vitro
Mahdy, E., El-Mezayen, H., Elmowafi, E., Mohamed, S. (2017). Anti-Diabetic Effect of Balanites Aegyptiacea Leaves Extract (Heglig) by Regulation of Erythrocyte Glucose Uptake in Diabetic Patients Type 2 in Vitro. EKB Journal Management System, 67(2), 528-535. doi: 10.12816/0037802
El-Sayed M. El-Sayed Mahdy; Hatem A. El-Mezayen; El-Mowafi Abdo Elmowafi; Shaimaa Sabry Mohamed. "Anti-Diabetic Effect of Balanites Aegyptiacea Leaves Extract (Heglig) by Regulation of Erythrocyte Glucose Uptake in Diabetic Patients Type 2 in Vitro". EKB Journal Management System, 67, 2, 2017, 528-535. doi: 10.12816/0037802
Mahdy, E., El-Mezayen, H., Elmowafi, E., Mohamed, S. (2017). 'Anti-Diabetic Effect of Balanites Aegyptiacea Leaves Extract (Heglig) by Regulation of Erythrocyte Glucose Uptake in Diabetic Patients Type 2 in Vitro', EKB Journal Management System, 67(2), pp. 528-535. doi: 10.12816/0037802
Mahdy, E., El-Mezayen, H., Elmowafi, E., Mohamed, S. Anti-Diabetic Effect of Balanites Aegyptiacea Leaves Extract (Heglig) by Regulation of Erythrocyte Glucose Uptake in Diabetic Patients Type 2 in Vitro. EKB Journal Management System, 2017; 67(2): 528-535. doi: 10.12816/0037802

Anti-Diabetic Effect of Balanites Aegyptiacea Leaves Extract (Heglig) by Regulation of Erythrocyte Glucose Uptake in Diabetic Patients Type 2 in Vitro

The Egyptian Journal of Hospital Medicine
Article 2, Volume 67, Issue 2, April 2017, Page 528-535  XML PDF (257.45 K)
Document Type: Original Article
DOI: 10.12816/0037802
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Authors
El-Sayed M. El-Sayed Mahdy1; Hatem A. El-Mezayen1; El-Mowafi Abdo Elmowafi2; Shaimaa Sabry Mohamed3
1Biochemistry Unit, Chemistry Department Faculty of Science, Helwan University,
2Medicinal and Aromatic Plants Unit, Horticulture Research Institute and National Gene Bank, Agricultural Research Center and
3Medicinal Plant Department, Horticulture Institute Agricultural Research Center
Abstract
Background: in Diabetes, the increase in the oxidative stress and decrease in the antioxidant defense may elevate he susceptibility of diabetic patients to many pathological complications, oxidative induced cell damage has been proposed to play an important role in the etiology of numerous pathological conditions. So, the aim of the present study was to investigate the antioxidant potential of Alcoholic Leaves extract of Balanites aegyptiacea (Heglig) due to the presence of phenolic and flavonoids compounds on uptake of glucose in vitro by erythrocytes of diabetic patients.
Results: in hyperglycemic patients, erythrocytes malondialdehyde level was highly significantly increased (P<0.0001) than that of control. However, the erythrocytes glutathione content was highly significantly decreased (P< 0.0001) when compared to that of corresponding control values. The glucose uptake by erythrocytes of diabetic patients was highly significantly decreased (P < 0.0001) with increasing hyperglycemia (Fasting Blood glucose), while it was highly significantly elevated (P< 0.0001) after addition of Balanites aegyptiacae  leaves extract to the incubation medium. On the other hand, the malondialdehyde concentration was highly significantly reduced (P < 0.0001) on adding the extract. So, it could be concluded that , an appreciate support for enhancing Antioxidant supply from natural sources such Balanites aegyptiace leaves extract may help control blood glucose levels and prevent pathological complications of diabetes  
 
Keywords
Diabetes mellitus; Balanites Leaves Extract; phenolic and flavonoids cpd; Oxidative Stress; Human Erythrocytes
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