Effect of Acacia arabica gum on histochemical changes in the renal cortex of rats exposed to gamma radiation
Kandeal, H., Abdelhafez, H., Eid, F., Abd Elhady, A. (2021). Effect of Acacia arabica gum on histochemical changes in the renal cortex of rats exposed to gamma radiation. EKB Journal Management System, 3(1), 1-18. doi: 10.21608/jmals.2021.142591
Heba Ahmed Mohamed Kandeal; Hemmat Mansour Abdelhafez; Fatma Ahmed Eid; Amr Mahmoud Abd Elhady. "Effect of Acacia arabica gum on histochemical changes in the renal cortex of rats exposed to gamma radiation". EKB Journal Management System, 3, 1, 2021, 1-18. doi: 10.21608/jmals.2021.142591
Kandeal, H., Abdelhafez, H., Eid, F., Abd Elhady, A. (2021). 'Effect of Acacia arabica gum on histochemical changes in the renal cortex of rats exposed to gamma radiation', EKB Journal Management System, 3(1), pp. 1-18. doi: 10.21608/jmals.2021.142591
Kandeal, H., Abdelhafez, H., Eid, F., Abd Elhady, A. Effect of Acacia arabica gum on histochemical changes in the renal cortex of rats exposed to gamma radiation. EKB Journal Management System, 2021; 3(1): 1-18. doi: 10.21608/jmals.2021.142591

Effect of Acacia arabica gum on histochemical changes in the renal cortex of rats exposed to gamma radiation

Journal of Medical and Life Science
Article 1, Volume 3, Issue 1, March 2021, Page 1-18  XML PDF (2.53 MB)
Document Type: Original Article
DOI: 10.21608/jmals.2021.142591
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Authors
Heba Ahmed Mohamed Kandeal1; Hemmat Mansour Abdelhafez1; Fatma Ahmed Eid1; Amr Mahmoud Abd Elhady2
1Zoology Department, Faculty of Science, AL-Azhar University, Egypt
2Misr University for Science and Technology, Egypt
Abstract
Objective: Lately, gum Arabic (GA) is traditionally used in Middle East countries to ameliorate renal function of patients with chronic renal failure (CRF). This action is controversial and it is still experimentally under evaluation. We aimed to shed more light on the potential effects of GA against γ-rays-induced nephrotoxicity in irradiated rats. Forty-eight male albino Sprague–Dawley rats were divided into four groups: control group(C), irradiated groups (R) 5Gy, gum Arabic groups (GA) 25 mg/kg orally administrated for 3 weeks, and  GA+R groups, rats were treated orally with 25 mg /kg GA for one week before and three weeks after irradiation (GA+R). The experimental rats were sacrificed after 7 and 21 days of irradiation. Histochemical examination of kidney cortex tissue of R groups showed significantly decreased PAS-positive materials, total protein content, and total DNA content, but it significantly increased amyloid β–protein content relative to the control group. While treatment with GA before and after irradiation showed a non-significant change in PAS-positive materials and the content of total protein, total DNA, and amyloid β–protein throughout the examined kidney cortex. According to the results obtained in the current study using GA as a natural agent showed a strong cytoprotective effect against the histochemical changes due to its radioprotective effect.
Keywords
Gum Arabic; Radiation; Histochemistry; Kidney; Rats
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