2- (3, 4- Dimethylphenyl - 3- [3, 4-Dichloro (or 3, 4-Dimethyl) Benzoyl])-Propanoic Acids as Precursors in the Synthesis of Some Heterocyclic Compounds | ||||
| Egyptian Journal of Chemistry | ||||
| Article 1, Volume 54, Issue 5, October 2012, Page 579-593 PDF (300.61 K) | ||||
| DOI: 10.21608/ejchem.2012.1427 | ||||
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| Abstract | ||||
| 3-(3,4-DICHLORO (or 3,4-dimethyl)benzoyl)] prop-2-enoic acids 1 ..... react with o-xylene and p-xylene under Friedel-Craft's reaction conditions giving acids 2 or 3, respectively. They were converted into the corresponding pyridazinone 4 derivatives upon treatment with N2H4 in boiling ethanol . The pyridazine derivatives 9,10,11 can be synthesized as a pro-drug due to their more potent and less peripheral effects than non-acidic or weakly acidic NSAIDs. Also, triazolopyridazine, oxazinone and furanone were also investigated. | ||||
| Keywords | ||||
| 3-Aroylprop-2- enoic acids; Pyridazinone; Triazolopyridazine; furanone; Pyridine; Oxime and Oxazinone | ||||
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