Antimicrobial Activities of Some Novel Synthesized Aryl-pyrazole, Isoxazole, Pyran and Pyridine Derivatives from 3-Aryl-1- (2-naphthyl) Prop-2-en-1-ones | ||||
| Egyptian Journal of Chemistry | ||||
| Article 3, Volume 54, Issue 5, October 2012, Page 609-622 PDF (401.69 K) | ||||
| DOI: 10.21608/ejchem.2011.1429 | ||||
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| Abstract | ||||
| 3-ARYL-1-(2-naphthyl)prop-2-en-1-ones (1) were reacted with .......hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride as nitrogen nucleophiles and with malononitrile, cyclohexanone, cyclopentanone as carbon nucleophiles to afford the corresponding dihydropyrazole 2,3and isoxazole 4 derivatives successively. Furthermore, cyanoamino pyran 5 and cyanoamino pyridine 6 derivatives were obtained. Additionally, a novel series of 1,5- diketone derivatives 7 and 8 were obtained, synthesized by base catalysed addition of cyclohexanone or cyclopentanone to compound 1. The latter compounds 7 and 8 were reacted with hydrazine hydrate to afford the respective hydrazide 9 and 10. Some of these compounds have been screened for antimicrobial activities. The structure assignments are based on the analytical and spectroscopic results. | ||||
| Keywords | ||||
| α; β-Unsaturated ketones; 1; 5-Diketones; Nicotinonitriles; pyrazole; Isoxazole; Pyran and pyridine derivatives and Antimicrobial activity | ||||
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