Design and Synthesis of New Curcuminoid Compounds and their Derivatives as Antioxidant Agents | ||||
| Egyptian Journal of Chemistry | ||||
| Article 44, Volume 64, Issue 4, April 2021, Page 2173-2183 PDF (915.58 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.49070.3005 | ||||
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| Authors | ||||
Rehab Abood 1; Tahseen Abdul Qader Alsalim  2; Einas Abdul Aziz Abood3
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| 1Department of Chemistry, Education college for Pure Sciences, University of Basrah, Basrah, Iraq | ||||
| 2department of Chemistry, Faculty of Education for pure sciences, university of Basrah, Basrah, Iraq | ||||
| 3Polymer Research Center, University of Basrah, Basrah, Iraq. | ||||
| Abstract | ||||
| A series of new curcumin analogues and their derivatives were synthesized by reacting curcumin analogues with various substituted hydrazine compounds to afford new pyrazol derivatives. The preparation of ether and ester derivatives was also carried out. All synthesized compounds were characterized using FT-IR, 1HNMR, 13CNMR, and MS-ESI. The evaluations of these compounds have shown a good inhibition activity as antioxidant agents against the stable radical of diphenylpicrylhydrazyl (DPPH). Findings from this work demonstrated a high inhibition activity in compounds substituted with hydroxyl phenol groups in comparison with compounds with other groups. | ||||
| Keywords | ||||
| Curcumin; Curcuminoids; Pyrazol; Antioxidant; DPPH | ||||
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