Maternal Vitamin D level and Early Pregnancy Loss A Nested Case Control Study | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 2, Volume 25, Issue 1 - Serial Number 11106352, January 2021, Page 12-19 PDF (1.95 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2021.143078 | ||||
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| Authors | ||||
Ahmed A El-Zayadi  1; Dina Hussein Ibrahim El-Araby, Karam Mohammed Bayoumy, Nermeen Ahmed Mostafa El-Ghareeb2
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| 1Department of Obstetrics and Gynecology, Mansoura University Hospitals, Elgomhouria St., City 35111, Dakahlia, Egypt | ||||
| 2Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University | ||||
| Abstract | ||||
| Objective: To assess the role of vitamin D deficiency and early pregnancy loss. Patient and Method: A nested case control study conducted in outpatient antenatal care clinic under supervision of Ain Shams University Maternity hospital from the period of March 2020 to June 2020. Pregnant ladies in the first trimester were screened for eligibility criteria.Blood samples were taken from the participants at the time of presentation. All participants were followed till the end of the first trimester to report cases of miscarriage. Vitamin d was assessed for the 40 women who suffered from miscarriage (cases) and for 40 selected controls.The primary outcome was the relation between vitamin d level and early pregnancy loss. Secondary outcome was the relation between vitamin d deficiency and obesity. Results: Our findings showed that the miscarriage groupwas significantly olderthan control group as p < 0.001 and BMI was significantly higher as p < 0.007.The mean value of 25(OH)D was significantly lower among miscarriage group (21.0±8.5) than control group (26.5±8.3) as p=0.005. And the majority of miscarriage group < br />(42.5%) had 25(OH)D deficiency while (40.0%)&(17.5%) of cases had either 25(OH)D insufficiencyor sufficiency which significantly different than control group (p=0.049).25(OH)D ≤24.5 (ng/mL) was a significant factor that increased the likelihood of first-trimestric miscarriage with sensitivity 80%.No significant differences according to BMI grades regarding 25(OH)D grades. Conclusion: Vitamin d deficiency is one of modifiable risk factors for first trimestric abortion. . Preconceptional vitamin D supplementation is an easy method for decreasing incidence of early pregnancy loss. | ||||
| Keywords | ||||
| vitamin D deficiency; early pregnancy loss; risk factors for miscarriage | ||||
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