Duration of stimulation in patients with polycystic ovarian syndrome undergoing ICSI: Does it affect the outcome? | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 5, Volume 25, Issue 1 - Serial Number 11106352, January 2021, Page 37-45 PDF (2.48 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2021.143088 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Mohamed Taman 
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| Lecturer Department of Obstetrics and Gynaecology Mansoura University Hospital Mansoura Faculty of Medicine Mansoura, Egypt | ||||
| Abstract | ||||
| Back ground: Oocyte and embryo quality are affected by the duration of ovarian stimulation in different categories of patients undergoing ICSI specially for those having polycystic ovarian syndrome as they undergo ovarian stimulation usinglow dose step up < br />antagonist protocol. Methods: Retrospective analysis of 139 patient underwent ovarian stimulatiaon using antagonist protocol and freeze all policy Results: Patients were divided into 3 groups according to the duration of ovarian stimulation (group A ≤ 8 days, group B 9-10 days, group C ≥ 11 days). We found that in spite of having no statistically significant difference in the total number of retrieved oocytes, there was statistically significant difference in the median number of germinal vesicle oocytes between group A and group C (3 (1-13) & 1(0-5) P value= 0.01). Also this difference is present between group B and group C (3 (1-11) & 1(0-5) P value= 0.01). For metaphase II oocytes there was a statistically significant difference in the median number between group A and group B (3 (0-8) & 5 (1-14) P value= 0.001). Also this difference is present between group A and group C (3 (0-8) & 3 (3-12) P value= 0.001).There was no statistically significant difference in the total number of embryos in between the 3 groups. Conclusion: We found that it seems to be safe to extend the duration of stimulation more than 8 days when treating patients with polycystic ovarian syndrome undergoing IVF/ICSI, as it was associated with more increase in mature oocytes (MII) | ||||
| Keywords | ||||
| polycystic ovarian syndrome; antagonist protocol; freeze all; ovarian hyperstimualtion syndrome; intracytoplasmic sperm injection | ||||
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