Expression of Discoidin Domain Receptor 2 in Colorectal Carcinoma: An Immunohistochemical Study
Ghareeb, R., Assaf, M., Ramadan, N., Harb, O. (2023). Expression of Discoidin Domain Receptor 2 in Colorectal Carcinoma: An Immunohistochemical Study. EKB Journal Management System, 29(2.1), 322-328. doi: 10.21608/zumj.2021.45870.1967
Rana Ahmed Ghareeb; Magda Ibrahim Assaf; Naglaa Ali Ramadan; Ola A. Harb. "Expression of Discoidin Domain Receptor 2 in Colorectal Carcinoma: An Immunohistochemical Study". EKB Journal Management System, 29, 2.1, 2023, 322-328. doi: 10.21608/zumj.2021.45870.1967
Ghareeb, R., Assaf, M., Ramadan, N., Harb, O. (2023). 'Expression of Discoidin Domain Receptor 2 in Colorectal Carcinoma: An Immunohistochemical Study', EKB Journal Management System, 29(2.1), pp. 322-328. doi: 10.21608/zumj.2021.45870.1967
Ghareeb, R., Assaf, M., Ramadan, N., Harb, O. Expression of Discoidin Domain Receptor 2 in Colorectal Carcinoma: An Immunohistochemical Study. EKB Journal Management System, 2023; 29(2.1): 322-328. doi: 10.21608/zumj.2021.45870.1967

Expression of Discoidin Domain Receptor 2 in Colorectal Carcinoma: An Immunohistochemical Study

Zagazig University Medical Journal
Article 25, Volume 29, Issue 2.1, March and April 2023, Page 322-328  XML PDF (622.44 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.45870.1967
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Authors
Rana Ahmed Ghareeb email 1; Magda Ibrahim Assaf2; Naglaa Ali Ramadan3; Ola A. Harb4
1pathology department, faculty of medicine, zagazig university, Egypt
2Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Pathology department, Faculty of medicine, Zagazig university, Egypt.
4zagazig university Egypt
Abstract
Background: Colorectal cancer (CRC) is considered a highly fatal disease. There is a strong need for novel markers to reach a proper outcome. Discoidin domain receptor 2 (DDR2) belongs to the family receptors tyrosine kinases with a possible relation towards CRC,as DDR2 has a proved role in development of other cancers by enhancing proliferation and metastasis.
Aim of the study: To evaluateDDR2 protein expression and its possible role in CRC for improved patient outcome and decreased morbidity and mortality.
Material and methods: Forty-eight patients diagnosed as colorectal carcinoma were encountered in this study.We analyzed the immunohistochemical expression of discoidin domain receptor 2 and then assessed the correlation of its expression with clinicopathological data.
Results: Discoidin domain receptor 2 expression is significantly associated with tumor size, infiltrating tumor border, presence of necrosis, tumor grade, tumor stage, lymphocytic infiltration and peritoneal spread (P=0.002, P=0.001, P=0.001, P=0.01, P=0.005, P=0.001, P=0.001, respectively), which all are associated with well-known indicators of poor prognosis.
Conclusion: Discoidin domain receptor 2 overexpression, being correlated with poor prognostic factors in colorectal carcinoma, confirm the role of DDR2 in poor outcome.
Keywords
CRC; discoidin domain receptor 2; DDR2; immunohistochemical; prognostic
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