Vitamin D Deficiency in Subclinical Hypothyroid Dysfunction Patients: A Case Control Study
Elamawy, M., Gouda Ameen, S. (2021). Vitamin D Deficiency in Subclinical Hypothyroid Dysfunction Patients: A Case Control Study. EKB Journal Management System, 38(1), 137-145. doi: 10.21608/bmfj.2021.143528
Medhat Elamawy; Seham Gouda Ameen. "Vitamin D Deficiency in Subclinical Hypothyroid Dysfunction Patients: A Case Control Study". EKB Journal Management System, 38, 1, 2021, 137-145. doi: 10.21608/bmfj.2021.143528
Elamawy, M., Gouda Ameen, S. (2021). 'Vitamin D Deficiency in Subclinical Hypothyroid Dysfunction Patients: A Case Control Study', EKB Journal Management System, 38(1), pp. 137-145. doi: 10.21608/bmfj.2021.143528
Elamawy, M., Gouda Ameen, S. Vitamin D Deficiency in Subclinical Hypothyroid Dysfunction Patients: A Case Control Study. EKB Journal Management System, 2021; 38(1): 137-145. doi: 10.21608/bmfj.2021.143528

Vitamin D Deficiency in Subclinical Hypothyroid Dysfunction Patients: A Case Control Study

Benha Medical Journal
Article 12, Volume 38, Issue 1, April 2021, Page 137-145  XML PDF (502.75 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2021.143528
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Authors
Medhat Elamawy1; Seham Gouda Ameen2
1Department of internal medicine, Benha faculty of medicine, Benha University, Egypt.
2Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt.
Abstract
Background: the prevalence of subclinical hypothyroidism worldwide is commoner than the overt disease. Limited studies discussed the vitamin D levels in subclinical hypothyroid patients. Giving vitamin D supplements may prevent form developing overt hypothyroidism. In this cross-sectional case-control study, we described the differences in the vitamin D of adult Saudis with and without subclinical hypothyroid dysfunction. Methods:  This is an observational single-center, retrospective, age, and sex matched, case-control study. A total of 60 subjects [41 healthy controls, 19 subclinical hypothyroid case] were included. 25(OH) vitamin D, TSH, free T4 and free T3 are measured in both groups. Results: Subjects with subclinical hypothyroid dysfunction had a significantly lower serum Vitamin D than controls (p value 0.016) although both groups fall below vitamin D sufficiency levels. Correlation is found between both vitamin D and TSH, p value 0.036. but it was found to be less statistically significant positive relation, r value is 0.279, (R square = .078, beta regression coefficient = -.055 and p value <0.0005) Conclusion: Patients with hypothyroid dysfunction showed much lower serum vitamin D compared to controls but it has not that big role in early hypothyroid disorders as shown in less significant relation.  
 
Keywords
Vitamin D; Hypothyroidism; Subclinical hypothyroidism
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