The Prophylactic Role of probiotics for Preterm Neonates
Aljubairah, W., Almubarak, E., Modawi, F., Alhabib, F., Binsalman, S., Saati, N., Shehatah, W., Al Dhban, A., Abulela, A., Alansari, A. (2017). The Prophylactic Role of probiotics for Preterm Neonates. EKB Journal Management System, 67(2), 697-704. doi: 10.12816/0037824
Waad Abdullah Saad Aljubairah; Eman Ahmad Almubarak; Fatimah Sharif Modawi; Fatimah Mohammed Alhabib; Sara Abdullah Binsalman; Nahla Shaker Saati; Wasan Usamah Shehatah; Abdullah Yahya Al Dhban; Areej Ahmad Abulela; Ammar Yasser Alansari. "The Prophylactic Role of probiotics for Preterm Neonates". EKB Journal Management System, 67, 2, 2017, 697-704. doi: 10.12816/0037824
Aljubairah, W., Almubarak, E., Modawi, F., Alhabib, F., Binsalman, S., Saati, N., Shehatah, W., Al Dhban, A., Abulela, A., Alansari, A. (2017). 'The Prophylactic Role of probiotics for Preterm Neonates', EKB Journal Management System, 67(2), pp. 697-704. doi: 10.12816/0037824
Aljubairah, W., Almubarak, E., Modawi, F., Alhabib, F., Binsalman, S., Saati, N., Shehatah, W., Al Dhban, A., Abulela, A., Alansari, A. The Prophylactic Role of probiotics for Preterm Neonates. EKB Journal Management System, 2017; 67(2): 697-704. doi: 10.12816/0037824

The Prophylactic Role of probiotics for Preterm Neonates

The Egyptian Journal of Hospital Medicine
Article 24, Volume 67, Issue 2, April 2017, Page 697-704  XML PDF (376.02 K)
Document Type: Original Article
DOI: 10.12816/0037824
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Authors
Waad Abdullah Saad Aljubairah1; Eman Ahmad Almubarak2; Fatimah Sharif Modawi3; Fatimah Mohammed Alhabib2; Sara Abdullah Binsalman4; Nahla Shaker Saati5; Wasan Usamah Shehatah4; Abdullah Yahya Al Dhban3; Areej Ahmad Abulela4; Ammar Yasser Alansari4
1Maternity & Children Hospital – Alhassa
2Imam Abdulrahman Bin Fisal University
3King Khalid University
4Ibn Sina National College
5Family Medicin/KAAU
Abstract
Background: Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Probiotics have been used for prevention and treatment of various medical conditions in children and adults. Studies on probiotics in premature infants have focused on normalizing intestinal flora, improvement in feeding intolerance, prevention of necrotizing enterocolitis which is the leading causes of death in the neonatal intensive care unit. 
Objective of the Study: was to provide an overview of the controversies regarding probiotic use in preterm infants and to shed light on the practical considerations for implementation of probiotic supplementation.
Methods: A Systematic search in the scientific database (Medline, Scopus, EMBASE , and Google Scholer) from 1990 to 2016 was conducted for all relevant retrospective studies including; retrospective , prospective and randomized controlled trials and cohort studies were analyzed and included based on the preset inclusion and exclusion criteria.
Results: The search results yielded 16 studies, 12 of which were RCTs with 2340 premature neonates and 4 meta-analyses with 10227 neonates which showed a significantly decreased incidence of Necrotizing Enterocolitis (NEC) (risk ratio, RR = 0.35, 95% confidence interval, 95% CI, 0.23-0.54; p = 0.0006) and mortality (RR = 0.46, 95% CI, 0.32-0.67; p < 0.0001). Sepsis did not differ significantly between the two groups (RR = 0.93, 95% CI, 0.76-1.15; p = 0.05).
Conclusion: there is a strong body of evidence supporting that Probiotic supplementation reduces the risk of NEC and mortality in preterm infants yet there is no sufficient evidence to support the optimal strain, dose and timing need further investigation.
 
Keywords
probiotics; Neonates; Lactobacillus reuteri; Necrotizing enterocolitis; premature infant
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