Anti-inflammatory Properties of the Crude Extract of Phyllostachys heterocycla in Two Different Models of Acute Inflammation in Experimental Rats | ||||
| Records of Pharmaceutical and Biomedical Sciences | ||||
| Article 5, Volume 5, Pharmacognosy-Microbiology - Serial Number 2, January 2021, Page 53-59 PDF (725.84 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/rpbs.2021.60202.1091 | ||||
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| Authors | ||||
Ahmed K. Ibrahim   1; Eman T. Mehanna 2; Reda F.A. Abdelhameed3; Eman S. Habib4; Koji Yamada5; Safwat A. Ahmed6; Amany K. Ibrahim6; Jihan M. Badr1
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| 1Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. | ||||
| 2Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt | ||||
| 3Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt | ||||
| 4pharmacognosy department,faculty of pharmacy,Suez canal university,Ismailia,Egypt. | ||||
| 5Garden for Medicinal Plants, Graduate School of Biomedical Sciences, Nagasaki University, Bunkyo-machi 1-14, Nagasaki 852-8521, Japan | ||||
| 6Faculty of Pharmacy - Suez Canal University | ||||
| Abstract | ||||
| The crude methanolic extract of Phyllostachys heterocycla was examined for the anti-inflammatory activity in rats using two different models of paw inflammation. Induction of edema was performed using 1% carrageenan in the first model and 2.5% formalin in the second model. The extract powder was dissolved in tween 80 and given orally for six consecutive days. Treatment with two doses (250 mg/kg and 500 mg/kg) of the extract of Phyllostachys heterocycla caused a dose-dependent reduction of paw thickness in both models. The anti-inflammatory effect of the crude extract of Phyllostachys heterocycla was also evaluated by determination of the serum levels of four inflammatory markers, where the serum levels of NF- κB, TNF-α, IL-1β and IL-6 were markedly increased in both models compared to the normal rats, with greater numbers recorded in the carrageenan-induced group. Treatment with both doses of the extract of Phyllostachys heterocycle led to a significant reeducation in all the detected markers in both the carrageenan and the formalin induced models, especially in case of the higher dose (500 mg/kg) that showed almost no significant different results compared to the normal group. In conclusion, the current preliminary study reports strong anti-inflammatory properties of Phyllostachys heterocycle extract. | ||||
| Keywords | ||||
| Phyllostachys heterocycle; rat paw edema; inflammatory markers; anti-inflammatory | ||||
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