Q10 and Xenobiotics Induce Nitration of Dicarbonyl –Xylulose Reductase (DCXR) via H2O2 /ONOO- in Human Skin | ||||
| Egyptian Academic Journal of Biological Sciences, E. Medical Entomology & Parasitology | ||||
| Article 6, Volume 9, Issue 1, December 2017, Page 59-68 PDF (562.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbse.2017.14477 | ||||
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| Author | ||||
| M. A. El. Salem | ||||
| Zoology Department, Faculty of Science, Zagazig University, Al Sharqia, Egypt | ||||
| Abstract | ||||
| Till today, there is a clear evidence for massive H2O2/ONOO- - mediated stress in the epidermal compartment of vitiligo. It has been demonstrated that this accumulation originates from numerous cellular (endogenous) and environmental sources. There are convincing results that these reactive species induce oxidation of many amino acids of various proteins/peptides which lead to structural modification, that can be a reason for partial or complete loss of functionality. It was shown that hydroquinone (HQ) has been utilised in topical preparations by Dermatologists in skin lightening and depigmentation of widespread vitiligo treatment. It was decided to investigate whether these patients exhibit quinone reduction via dicarbonyl xylulose reductase (DCXR) as this enzyme reduces quinones and xenobiotics. The results show that DCXR is markedly decreased and affected by H2O2 and ONOO-. The results were demonstrated by utilising in situ immunofluorescence labelling, Western blot, and FT- Raman spectroscopy. | ||||
| Keywords | ||||
| ROS; RNS; Vitiligo; quinones; xenobiotics | ||||
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