Chemical Synthesis of Some Novel 6-Aminouracil-2-Thiones and Their Glycoside Analogues | ||||
| Egyptian Journal of Chemistry | ||||
| Article 8, Volume 59, Issue 5, October 2016, Page 779-797 PDF (1.46 MB) | ||||
| DOI: 10.21608/ejchem.2016.1449 | ||||
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| Abstract | ||||
| 6-AMINOURACIL-2-THIONE (1) and its 5-bromo derivative 2 underwent alkylation yielding their respective S-alkyl products 4a-j. The reaction of compound 1 and aldehydes in the presence of chloroacetic acid afforded the respective thiazolopyrimidinyl acetamides 7a-d. The C-glycosides 8a,b and 9c-e were successfully prepared through condensing compound 1 and the appropriate sugar in the presence of chloroacetic acid. The behavior of certain S-alkyl derivative 4 towards amines and hydrazines was also studied. Structure elucidations for the new products were supported by compatible chemical and spectral measurements. | ||||
| Keywords | ||||
| Aminothiouracil; glycoside; Nucleoside; NMR and IR | ||||
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