Possible Role of Garlic Oil and Parsley Extract in Ameliorating Radiation-Induced Bone Loss in Female Rats | ||||
| Egyptian Journal of Radiation Sciences and Applications | ||||
| Article 6, Volume 24, Issue 1, June 2011, Page 87-100 PDF (426.55 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejrsa.2011.1456 | ||||
 View on SCiNiTO | ||||
| Abstract | ||||
| TO INVESTIGATE the possible protective effect of garlic oil and parsley extract against bone loss resulted in female virgin rats exposed to fractionated doses of γ-radiation (1Gy 3 times weekly for 5 weeks). Urinary calcium (uCa), calcium to creatinine ratio (Ca/Cr), hydroxyproline and serum phosphorus were measured as bone resorption biomarkers, while serum osteocalcine (OST) and serum alkaline phosphatase (ALP) were measured as bone formation biomarkers. Furthermore, nitric oxide (NO) which represents the balance in bone remodeling was measured. Malondiadehyde level (MDA) as well as superoxide dismutase activity (SOD) was measured as oxidative stress biomarkers. Female irradiated rats in the present study had significant increases in both bone resorption and bone formation biomarkers after 6 weeks from the last exposure to γ-radiation. Irradiated rats also had significant decreases in plasma NO indicating imbalance in bone remodeling as well as significant increase in oxidative stress biomarkers. Daily treatment with garlic oil extracted in olive oil improved all measured parameters except OST level, while the vehicle used for garlic oil (extra virgin olive oil) significantly decreased bone resorption biomarkers. Parsley extract induced normalization to all bone resorption and formation parameters measured in irradiated rats. Daily administration of garlic oil and parsley extract protected the bone from degeneration induced by exposure to fractionated doses of gamma radiation. | ||||
| Keywords | ||||
| γ-irradiation; garlic oil; parsley extract | ||||
|
Statistics Article View: 238 PDF Download: 293 |
||||
