The Impact of the serum level of trace elements on the severity of neuropathy in type 2 Diabetic patients | ||||
| Zagazig University Medical Journal | ||||
| Article 30, Volume 29, Issue 2.1, March and April 2023, Page 178-184 PDF (368.77 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2021.51387.2029 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Rania Bahriz1; Sherif Fathy2; Ahmed Albehairy   3
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| 1Lecturer of Endocrinology and Diabetes, Faculty of Medicine, Mansoura University | ||||
| 2Assistant Lecturer of clinical pathology, Faculty of Medicine, Mansoura University, Egypt | ||||
| 3Lecturer of Endocrinology and Diabetes Faculty of Medicine, Mansoura University | ||||
| Abstract | ||||
| Background and aim: This study was designed in order to estimate the alterations in the levels of serum zinc, magnesium and copper in patients with type 2 diabetes mellitus with diabetic peripheral neuropathy in comparison to those without neuropathy and their relation to duration of diabetes and glycemic control. Method: 71 patients with Type 2 diabetes recruited and divided into 2 groups: Group 1: 47 patients with diabetic neuropathy and Group 2: 24 patients with type 2 diabetes without diabetic neuropathy. The presence and absence of neuropathy was assessed using neuropathy disability score and neuropathy symptom score. Full history and examination were taken from all participants. Neuropathy symptom score and neuropathy disability score was assessed. A blood sample was taken for measuring A1c, serum zinc, magnesium, and copper Results: There was a significant difference between both groups as regard duration of diabetes and serum copper level (P value< 0.05). After performing linear regression analysis, the duration of Diabetes was the significant risk factor for the diabetic neuropathy symptoms. On the other hand, there was no significant difference between the 2 groups as regard serum zinc, serum magnesium, glycated hemoglobin, age, sex, and hypertension. Conclusion: High serum CU and low serum Mg and Zn are not independent risk factors for diabetic neuropathy as previously thought, and its alterations in diabetic patients may be due to the hyperglycemia itself | ||||
| Keywords | ||||
| Zinc; neuropathy; Magnesium; Trace elements | ||||
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