Role of Prostatic Stem Cell Antigen (PSCA) and Snail in Different Prostatic Lesions) (An immunohistochemical study | ||||
| Benha Medical Journal | ||||
| Article 11, Volume 38, Academic issue, February 2021, Page 166-185 PDF (2.1 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2021.146411 | ||||
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| Authors | ||||
| Marwa Abd Allah; Nancy Abo Elgheit Dawood; Ranih Amer; Taghreed Abd Elsamea; Abd Ellatif Elbalshy | ||||
| Department of pathology, Benha faculty of medicine, Benha University, Egypt. | ||||
| Abstract | ||||
| Background: Prostatic carcinoma (PCa) represents the second most common cancer, and the fifth leading cause of cancer death among males worldwide. PSCA is a GPI-anchored cell surface protein. It belongs to the Thy-1/Ly-6 family which shows a functional diversity ranging from T-cell activation to apoptosis regulation. Snail is one of zinc finger proteins which are transcriptional repressors of E-cadherin. Aim: To study PSCA and Snail expression in different prostatic lesions to evaluate their roles in PCa. Material and Methods: This retrospective study was done upon 80 different prostatic lesions; 17 cases of BPH, 13 cases of HGPIN, and 50 cases of PCa. PSCA and Snail immunostaining was done and assessed for each case. Results: There was a highly significant statistical correlation between both PSCA and Snail expressions and histopathological type (P-value<0.01). PSCA expression showed a highly significant statistical correlation with Gleason score, tumor grade and stage (P-value<0.01), and a significant correlation with PSA, and peri-neural invasion (P-value<0.05). Snail expression showed a highly significant statistical correlation with Gleason score and tumor grade (P-value<0.01), and a significant correlation with lymph node metastasis and tumor stage (P-value<0.05). There was a highly significant statistical correlation between PSCA and Snail immune-expression (P-value<0.01). Conclusion: PSCA and Snail expressions correlate with the most important prognostic clinicopathological variables in PCa, thus they may represent a useful predictor of prognosis. | ||||
| Keywords | ||||
| Prostatic carcinoma; PSCA; Snail | ||||
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